An intravenous injection of 2-fluoro-oestradiol simultaneously with an implantation-inducing dose of oestradiol reduced the number of implantation sites in delayed implanting hypophysectomized rats maintained with progesterone. Administration of 2-fluoro-oestradiol 1 h before or after oestradiol had no effect. Furthermore, injection of as much as 500 ng 2-fluoro-oestradiol 48 h before administr...

Introduction Oestrogens protect against coronary artery disease (CAD) [l-31. An estimated 2540% of this protective effect can be attributed to changes in fasting plasma lipids [4]. Low-density lipoprotein (LDL) cholesterol concentrations are reduced [5,6] as the result of enhanced clearance of atherogenic LDL particles by upregulated LDL receptors [7,8]. The production of highdensity lipoprotei...

Sexual disruption in wild fish has been linked to the contamination of river systems with steroid oestrogens, including the pharmaceutical 17α-ethinylestradiol, originating from domestic wastewaters. As analytical chemistry has advanced, more compounds derived from the human use of pharmaceuticals have been identified in the environment and questions have arisen as to whether these additional p...

STUDY OBJECTIVE The aim was to investigate the relationship between oral contraceptives, non-contraceptive oestrogens, and the risk of gallstone disease requiring surgery. DESIGN This was a hospital based case-control study carried out between 1987 and 1990. Main outcome measures were frequency of consumption of oral contraceptives and non-contraceptive oestrogens, and the corresponding multi...