نتایج جستجو برای: odn

تعداد نتایج: 1689  

Journal: :Journal of immunology 2002
Isabelle Miconnet Sylvain Koenig Daniel Speiser Arthur Krieg Philippe Guillaume Jean-Charles Cerottini Pedro Romero

The identification of CTL-defined tumor-associated Ags has allowed the development of new strategies for cancer immunotherapy. To potentiate the CTL responses, peptide-based vaccines require the coadministration of adjuvants. Because oligodeoxynucleotides (ODN) containing CpG motifs are strong immunostimulators, we analyzed the ability of CpG ODN to act as adjuvant of the CTL response against t...

Journal: :Journal of leukocyte biology 2002
B Jahrsdörfer R Jox L Mühlenhoff K Tschoep A Krug S Rothenfusser G Meinhardt B Emmerich S Endres G Hartmann

Inhibition of bcl-2 expression by antisense oligodeoxynucleotides (ODN) might render bcl-2 overexpressing malignant B cells more susceptible to chemotherapy. ODN containing unmethylated CG dinucleotides (CpG) are known to activate B cells. We studied the effects of two bcl-2 antisense ODN, with (G3139) or without CG dinucleotides (NOV 2009) within the sequence, and the effects of a nonantisense...

Journal: :Archives of ophthalmology 2005
Robert B Bhisitkul Gregory S Robinson Rachel S Moulton Kevin P Claffey Evangelos S Gragoudas Joan W Miller

OBJECTIVE To evaluate an antisense oligodeoxynucleotide (AS-ODN) targeted against vascular endothelial growth factor for its effects on ocular angiogenesis and its intraocular localization in a nonhuman primate model of iris neovascularization. METHODS Bilateral laser retinal vein occlusion was performed in monkeys, followed by intravitreal injections of a vascular endothelial growth factor-s...

Journal: :Journal of immunology 2000
G Hartmann R D Weeratna Z K Ballas P Payette S Blackwell I Suparto W L Rasmussen M Waldschmidt D Sajuthi R H Purcell H L Davis A M Krieg

Oligodeoxynucleotides (ODN) containing unmethylated CpG dinucleotides within specific sequence contexts (CpG motifs) are detected, like bacterial or viral DNA, as a danger signal by the vertebrate immune system. CpG ODN synthesized with a nuclease-resistant phosphorothioate backbone have been shown to be potent Th1-directed adjuvants in mice, but these motifs have been relatively inactive on pr...

Journal: :Respiratory Research 2007
Pascal Knuefermann Georg Baumgarten Alexander Koch Markus Schwederski Markus Velten Heidi Ehrentraut Jan Mersmann Rainer Meyer Andreas Hoeft Kai Zacharowski Christian Grohé

BACKGROUND Bacterial DNA containing motifs of unmethylated CpG dinucleotides (CpG-ODN) initiate an innate immune response mediated by the pattern recognition receptor Toll-like receptor 9 (TLR9). This leads in particular to the expression of proinflammatory mediators such as tumor necrosis factor (TNF-alpha) and interleukin-1beta (IL-1beta). TLR9 is expressed in human and murine pulmonary tissu...

Journal: :Developmental and comparative immunology 2005
Haiqi He Virginia K Lowry Pamela J Ferro Michael H Kogut

Synthetic oligodeoxynucleotide containing unmethylated CpG motif (CpG-ODN) is immune stimulatory to chicken heterophils. Recognition of CpG-ODN by chicken heterophils leads to the mobilization and release of granules. This CpG-ODN-induced heterophil degranulation was chicken serum (CS)-dependent. Heat-denaturation and membrane filtration of CS revealed that the active serum cofactor(s) was like...

Journal: :Journal of immunology 2004
Jane C Deng Thomas A Moore Michael W Newstead Xianying Zeng Arthur M Krieg Theodore J Standiford

Bacterial pneumonia is a leading cause of mortality in the United States. Innate immune responses, including type-1 cytokine production, are critical to the effective clearance of bacterial pathogens from the lung. Synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG dinucleotide motifs (CpG ODN), which mimic the effects of bacterial DNA, have been shown to enhance type-1 cytokine ...

Journal: :Oncology reports 2012
Atsushi Kajiwara Hiroyoshi Doi Junichi Eguchi Shigeaki Ishii Ayako Hiraide-Sasagawa Masashi Sakaki Risa Omori Kazumasa Hiroishi Michio Imawari

Because IL-4 and CpG oligodeoxynucleotides (CpG-ODNs) are immune stimulants, we evaluated the antitumor effects of IL-4 gene therapy and CpG-ODN treatment in a poorly immunogenic murine cancer model. We used a murine colorectal cancer MC38 cell line overexpressing the IL-4 gene (MC38-IL4). Incubation with MC38-IL4 and CpG-ODN enhanced bone marrow-derived dendritic cell (DC) maturation in vitro....

Journal: :Infection and immunity 2003
Susantha Gomis Lorne Babiuk Dale L Godson Brenda Allan Tannis Thrush Hugh Townsend Philip Willson Edwin Waters Rolf Hecker Andrew Potter

Synthetic oligodeoxynucleotides (ODN) containing CpG motifs (CpG-ODN) have been shown to be effective immunoprotective agents in murine models for a variety of viral, intracellular bacterial, and protozoan infections. Until now, the use of CpG-ODN to protect against extracellular bacterial infections has not been reported. The objective of this study was to investigate the effect of CpG-ODN aga...

Journal: :Cancer prevention research 2011
Hidekazu Ikeuchi Takeshi Kinjo Dennis M Klinman

Inflammation contributes to the development of papillomas and squamous cell carcinomas in the well-established 7,12-dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol-l3-acetate (TPA) model of skin carcinogenesis. Synthetic oligonucleotides (ODN) containing repetitive TTAGGG motifs have been shown to block deleterious inflammatory reactions in murine models of autoimmunity, pneumonitis,...

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