Introduction: Recent studies have shown that myocardial T1 after administration of an extracellular Gd-based contrast agent and the myocardial partition coefficient represent novel biomarkers of diffuse fibrosis, which may be not recognized by standard methods for imaging delayed contrast enhancement [1-2]. Such novel markers of diffuse fibrosis and remodeling of the extracellular matrix could ...

We have used first principles methods to calculate the partitioning of water between perovskite and ringwoodite under lower mantle and Fe-free conditions. We find that incorporation of water into ringwoodite is more favourable than into perovskite by about 0.25 eV per formula unit, or about 24 kJ/mol. This translates to a ringwoodite to perovskite partition coefficient of between 10 and 13, dep...

The purpose of this study was to investigate the effects of size and type of incorporated model molecules on the polymer degradation and release profile from thermosensitive triblock copolymer based controlled delivery systems. In vitro release of the incorporated molecules demonstrated slow release for risperidone (molecular weight (Mw) = 410.48 Da; partition coefficient (Ko/w) = 3.49), while ...

The inositol-containing phosphatides of soy beans have been the subject of a number of investigations (l-7) since 1939 when Klenk and Sakai (8) first reported the presence of inositol in soy bean phosphatides. Previous work at the Northern Regional Research Laboratory (3) has shown that the alcohol-insoluble portion of soy bean phosphatides can be separated into two inositol-containing fraction...

E. T. Petersen, K. C. van de Ven, I. Zimine, X. Golay Neuroradiology, National Neuroscience Institute, Singapore, Singapore, Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, Singapore Bioimaging Consortium, ASTAR, Singapore, Singapore INTRODUCTION: Perfusion is vital for the homeostasis and thereby survival of an organ and as such is a very important physiolog...

Measurements of diffusion and partitioning of solutes having molecular weights ranging 180-66 000 in PVA gel membranes with various crosslinking degree were carried out. With increasing solute size or decreasing number of average molecular weight between crosslinks of the membranes, both the solute permeability and partition coefficient decreased. In spite of similar solute sizes, the more hydr...