Elevated homocysteine (Hcy) levels are observed in two apparently unrelated diseases: neural-tube defects (NTD) and premature vascular disease. Defective human methionine synthase (MS) could result in elevated Hcy levels. We sequenced the coding region of MS in 8 hyperhomocysteinaemic patients (4 NTD patients and 4 patients with pregnancies complicated by spiral arterial disease, SAD). We ident...

Nitrogen limitation in Escherichia coli activates about 100 genes. Their expression requires the response regulator NtrC (also called nitrogen regulator I or NR(I)). Phosphorylation of the amino-terminal domain (NTD) of NtrC activates the neighboring central domain and leads to transcriptional activation from promoters that require sigma(54)-containing RNA polymerase. The NTD has five beta stra...

Parkinson's disease (PD) presents with extensive heterogeneity in symptomatology, inviting examination of disease subtypes. One significant categorization is by whether patients present at onset with tremor as the dominant symptom (TD) or with nontremor symptoms (NTD). We examined differences in quality of life between TD and NTD patients using the Parkinson's Disease Questionnaire-39 (PDQ-39),...

Ionotropic glutamate receptors (iGluRs) harbor two extracellular domains: the membrane-proximal ligand-binding domain (LBD) and the distal N-terminal domain (NTD). These are involved in signal sensing: the LBD binds L-glutamate, which activates the receptor channel. Ligand binding to the NTD modulates channel function in the NMDA receptor subfamily of iGluRs, which has not been observed for the...

The evolutionarily conserved Par-3/Par-6/aPKC complex is essential for the establishment and maintenance of polarity of a wide range of cells. Both Par-3 and Par-6 are PDZ domain containing scaffold proteins capable of binding to polarity regulatory proteins. In addition to three PDZ domains, Par-3 also contains a conserved N-terminal oligomerization domain (NTD) that is essential for proper su...

OBJECTIVE To study the effect of increased folic acid intake on the prevalence of neural tube defects (NTD) in The Netherlands. STUDY DESIGN Using the capture-recapture method, the prevalence of NTD was estimated on the basis of five different registries on births affected by NTD. RESULTS Total prevalence over the 1988-1998 period varied between 1.43 and 1.96 per 1000 live and still births....

N-terminal Domain of SARS-CoV-2 Spike Protein In article number 2100152, Yao Li, Tong Wang, Haipeng Gong, and co-workers propose the “wedge” model to demonstrate regulatory function domain (NTD) protein. The NTD typically wedges in prohibit receptor binding domain's (RBD's) movements it occasionally moves out allow RBD tilt downward.

OBJECTIVE To review the impact of folic acid fortification of flour on the prevalence of neural tube defects (NTD). DESIGN Systematic review of the literature on MEDLINE via PubMed, Scopus, OvidSP and LILACS (Latin American and Caribbean Health Sciences Literature) reporting the impact of folic acid fortification of flour on the prevalence of NTD in 2000-2011. Focusing on Santiago of Chile's ...

Non-negative Canonical Polyadic decomposition (NCPD) and non-negative Tucker decomposition (NTD) were compared for extracting the multi-domain feature of visual mismatch negativity (vMMN), a small event-related potential (ERP), for the cognitive research. Since signal-to-noise ratio in vMMN is low, NTD outperformed NCPD. Moreover, we proposed an approach to select the multi-domain feature of an...