UNLABELLED The Na(+) -taurocholate cotransporting polypeptide (NTCP) mediates uptake of conjugated bile acids (BAs) and is localized at the basolateral membrane of hepatocytes. It has recently been recognized as the receptor mediating hepatocyte-specific entry of hepatitis B virus and hepatitis delta virus. Myrcludex B, a peptide inhibitor of hepatitis B virus entry, is assumed to specifically ...

AIM To create a presentation method of TCP and NTCP distributions calculated based on dose distribution for a selected CT slice. MATERIALS AND METHODS Three 24-bit colour maps - of dose distribution, delineated structures and CT information - were converted into m-by-n-by-3 data arrays, containing intensities of red, green, and blue colour components for each pixel. All calculations were perf...

Vectorial transport of bile acids across hepatocytes is a major driving force for bile flow, and bile acid retention in the liver causes hepatotoxicity. The basolateral and apical transporters for bile acids are thought to be targets of drugs that induce cholestasis. Previously, we constructed polarized LLC-PK1 cells that express both a major bile acid uptake transporter human Na+/taurocholate ...

A bio-anatomical quality assurance (QA) method employing tumor control probability (TCP) and normal tissue complication probability (NTCP) is described that can integrate radiobiological effects into intensity-modulated radiation therapy (IMRT). We evaluated the variations in the radiobiological effects caused by random errors (r-errors) and systematic errors (s-errors) by evaluating TCP and NT...

Background: Modern radiotherapy requires accurate contouring which may suffer in the postsurgical setting. We estimated post-prostatectomy interand intra-rater contouring reliability and assessed the effect on bladder and rectal normal tissue complication probability (NTCP). Methods: Four physicians each contoured two different treatment plans, separated by at least seven days, on 15 patients r...

Background Bile salts undergo enterohepatic circulation which is essential for bile salt homeostasis. From the biliary tract, they are excreted into the small intestine, absorbed into the blood and transported back to the liver. The sinusoidal uptake systems of the liver efficiently extract bile salts and other substrates from portal blood. In rat liver, these systems include Ntcp (sodium tauro...

AIM To determine the variability/conservation of the domain of hepatitis B virus (HBV) preS1 region that interacts with sodium-taurocholate cotransporting polypeptide (hereafter, NTCP-interacting domain) and the prevalence of the rs2296651 polymorphism (S267F, NTCP variant) in a Spanish population. METHODS Serum samples from 246 individuals were included and divided into 3 groups: patients wi...

S5 ______________________________________________________________________________________________________ (∆NTCP). In the Netherlands, a national consensus has been reached regarding the threshold for (∆NTCP Finally, the potential benefits of protons can be clinically validated in step 4, based on external validation of the NTCPmodels when patients are treated with protons. The modelbased appro...

Hepatitis B virus (HBV) constitutes a serious public health problem worldwide, and its chronic infection elevates the risk of developing liver cirrhosis and hepatocellular carcinoma. The current anti-HBV agents are limited to interferon-based regimens and nucleos(t)ide analogs, therefore, the development of new anti-HBV drugs is greatly needed. Recently, sodium taurocholate cotransporting polyp...

background: in order to improve the evaluation of possible rectal toxicity based on the rectal normal tissue complication probability (ntcp), we consider the fractional dependence of the ntcp on the wall thickness (tw) and rectal displacement (rm). materials and methods: the two-dimensional ntcp model (ntcp2d) was developed using radiotherapy plans of ten randomly selected patients with prostat...