Neural stem cells (NSCs) can self-renew and give rise to neurons, astrocytes and oligodendrocytes. NSCs are found in the central nervous system (CNS) of mammalian organisms, and represent a promising resource for both fundamental research and CNS repair. Animal models of CNS damage have highlighted the potential benefit of NSC-based approaches. Here we review the progress in the field of NSC bi...

The mitochondrial DNA (mtDNA) of neural stem cells (NSCs) is vulnerable to oxidation damage. Subtle manipulations of the cellular redox state affect mtDNA integrity in addition to regulating the NSC differentiation lineage, suggesting a molecular link between mtDNA integrity and regulation of differentiation. Here we show that 8-oxoguanine DNA glycosylase (OGG1) is essential for repair of mtDNA...

PURPOSE To evaluate the feasibility of administering NSC 655649, a water-soluble rebeccamycin analogue that inhibits both topoisomerases I and II, in combination with cisplatin (CDDP) in adults with solid malignancies. Major toxicologic and pharmacologic differences between the two sequences of drug administration were also assessed. EXPERIMENTAL DESIGN NSC 655649 was administered as a 60-min...

Chemotherapy is a vital therapeutic strategy for castration-resistant prostate cancer (CRPC). We have previously shown that NSC606985 (NSC), a camptothecin (CPT) analog, induced cell apoptosis via interacting with topoisomerase I (Topo I) in prostate cancer cells. In the present study, the effect and mechanism of CPT analogs in LAPC4 cells were investigated. LAPC-4 cells were treated with NSC, ...

Cdc25 dual-specificity phosphatases coordinate cell cycle progression and cellular signaling. Consequently, Cdc25 inhibitors represent potential anticancer agents. We evaluated >10,000 compounds for inhibition of human Cdc25 phosphatases and identified many potent and selective inhibitors, which all contained a quinone. Bioreductive enzymes frequently detoxify or activate quinones. Therefore, w...

We present a high-level parallel calculus for nested sequences, NSC, ooered as a possible theoretical \core" of an entire class of collection-oriented parallel languages. NSC is based on while-loops as opposed to general recursion. A formal, machine independent deenition of the parallel time complexity and the work complexity of programs in NSC is given. Our main results are: (1) We give a tran...

PURPOSE: There is growing evidence that nonsyndromic craniosynostosis (NSC) is associated with functional disabilities in learning and language. To further characterize the neurocognitive changes associated with this condition, we have used auditory event-related potentials (ERPs) to study language acquisition in NSC infants. Mismatch negativity (MMN) is an ERP component that has been used to p...

Stored non-structural carbohydrates (NSC) have been proposed as a key determinant of drought resistance in plants. However, the evidence for this role is controversial, as it comes mostly from observational, short-term studies. Here, we take advantage of a long-term experimental throughfall reduction to elucidate the response of NSC to increased drought 14 years after the beginning of the treat...

Understanding the role of stored non-structural carbohydrates (NSC) in trees has been a long-term goal tree physiology research. A study published this issue strengthens possible NSC storage as key to mitigate drought effects.

thalanilides (10) in animals (2—7, 9, 13, 15, 20, 21, 24, 28— 31, 33, 34) and tissue culture (12, 23, 32),@clinical trial of these compounds has been described by various investi gators (16—18,22). This report deals with the absorption and excretion of the radioactivity of C'4-labeled 4' ,4―bis(2-imidazolin-2-yl) 2-chloroterephthalanilide dihydro chloride (NSC-38280)4 after P.O. and I.V...