نتایج جستجو برای: nr5a1
تعداد نتایج: 360 فیلتر نتایج به سال:
Introducción: los trastornos del desarrollo sexual se definen como afecciones congénitas en las que el sexo cromosómico gonadal o anatómico es atípico. Son anormalidades raras, ocurren 1 de cada 1000 a 4500 nacidos vivos.Dentro causas más comunes encuentran: la hiperplasia suprarrenal congénita debido deficiencia 21-hidroxilasa un individuo XX, mosaicismos involucra 45, X/46, XY tiene amplio es...
The liver receptor homolog-1 (LRH-1; NR5A2) belongs to nuclear hormone receptor superfamily, and is expressed mainly in the liver, intestine, exocrine pancreas, and ovary. It binds DNA as a monomer, and is best known as a regulator of hepatic expression of the key bile acid biosynthetic enzyme cholesterol 7alpha hydroxylase (Cyp7A1). It is also expressed in embryonic stem cells and the initial ...
Zinc oxide nanopartciles (ZnONPs) involved in advanced technologies, and their wide-scale use in consumer market makes human beings more prone to the exposure to ZnONPs. The present study was undertaken to evaluate amelioration of ZnONP-induced toxicities with querectin in male albino rats. ZnONPs-treated rats showed a significant decrease in sperm cell count, sperm motility, live and normal sp...
Congenital defects in genital and/or gonadal development occur in 1 in 1000 humans, but the molecular basis for these defects in most cases remains undefined. We show that the basic helix-loop-helix transcription factor Pod1 (capsulin/epicardin/Tcf21) is essential for normal development of the testes and ovaries, and hence for sexual differentiation. The gonads of Pod1 knockout (KO) mice were m...
Leydig cells (LCs) play crucial roles in producing testosterone, and their dysfunction leads to male hypogonadism. LC transplantation is a promising alternative therapy for male hypogonadism. However, the source of LCs limits this strategy for clinical applications. Here, we report our success in reprogramming mice fibroblasts into LCs by expressing three transcriptional factors, Dmrt1, Gata4, ...
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