Fibrinogen-like protein 2 (fgl2) is highly expressed in microvascular endothelial cells in diseases associated with microcirculatory disturbances and plays a crucial role in microthrombosis. Previous studies have demonstrated that the Ser89 residue is a critical site for mouse fgl2 prothrombinase activity. The aim of this study was to investigate the prothrombinase inhibitory ability of antibod...

The relaxation dynamics of dipropylene glycol and tripropylene glycol (nPG-n=2,3) water solutions on the nPG-rich side has been studied by broadband dielectric spectroscopy and differential scanning calorimetry in the temperature range of 130-280 K. Two relaxation processes are observed for all the hydration levels; the slower process (I) is related to the alpha relaxation of the solution where...

INTRODUCTION Root canal-treated teeth are weaker than vital teeth and are more susceptible to fractures. Therefore, special precautions should be adhered to, such as the use of various types of cast or prefabricated posts. Regarding the effect of post material on fracture resistance of teeth, the aim of this in vitro study was to evaluate the effect of non-precious gold color alloy (NPG) and ni...

Abstract We study the convergence of several natural policy gradient (NPG) methods in infinite-horizon discounted Markov decision processes with regular parametrizations. For a variety NPGs and reward functions we show that trajectories state-action space are solutions flows respect to Hessian geometries, based on which obtain global guarantees rates. In particular, linear for unregularized reg...

The X-ray crystal structure of a conformationally constrained mutant of the Escherichia coli lactose permease (the LacY double-Trp mutant Gly-46→Trp/Gly-262→Trp) with bound p-nitrophenyl-α-d-galactopyranoside (α-NPG), a high-affinity lactose analog, is described. With the exception of Glu-126 (helix IV), side chains Trp-151 (helix V), Glu-269 (helix VIII), Arg-144 (helix V), His-322 (helix X), ...

The smart integration of multiple devices in a single functional unit is boosting the advent compact optical sensors for on-site analysis. Nevertheless, development miniaturized and cost-effective plasmonic hampered by strict angular constraints detection scheme, which are fulfilled through bulky components. Here, an ultracompact system plasmonic-sensing demonstrated organic light-emitting tran...

We have investigated self-assembled molecular monolayers (SAMs) of a novel thiol-bearing anthraquinone derivative AQ(OMe) (1-amino-4-((3-mercapto-5-(methoxycarbonyl)phenyl)amino)-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid) with multifarious protonation sites, on nanoporous gold (NPG) electrode surfaces. employ cyclic voltammetry, electrochemical impedance spectroscopy and X-ray photoelec...

Hole doping of cuprate superconductors removes electrons from the antibonding planar Cu3dx2−y2O2pxy states; thus increasing doping is expected to shorten the planar Cu–O bonds. All accessible crystallographic data, however, give evidence for a significant deviation from the Pauling-type contraction of covalent bonds on increasing covalency. Between the onset of superconductivity at nI−M = 0.07(...

Plasmonic metal nanostructures have shown great potential in sensing applications. Among various materials and structures, monolithic nanoporous gold disks (NPGD) have several unique features such as three-dimensional (3D) porous network, large surface area, tunable plasmonic resonance, high-density hot-spots, and excellent architectural integrity and environmental stability. They exhibit a gre...