نتایج جستجو برای: nos3

تعداد نتایج: 5369  

Journal: :Medical principles and practice : international journal of the Kuwait University, Health Science Centre 2010
Rami J Al Sallout Fadel A Sharif

OBJECTIVE This study was conducted to investigate the correlation between spontaneous recurrent miscarriage (RM) and common polymorphisms in angiotensin-converting enzyme (ACE), plasminogen activator inhibitor 1 (PAI-1) and endothelium-derived nitric oxide synthase 3 (NOS3) genes among women experiencing RM in the Gaza Strip. METHODS The presence of these genetic profiles was determined for 1...

Journal: :Asian Pacific journal of cancer prevention : APJCP 2016
C Basmaci M Pehlivan Ag Tomatir T Sever V Okan M Yilmaz S Oguzkan-Balci S Pehlivan

It is not clear how gene polymorphisms affecting drugs can contributes totheir efficacy in multiple myeloma (MM). We here aimed to explore associations among gene polymorphisms of tumor necrosis factor alpha (TNFα), nitric oxide synthesis 3 (NOS3) and multi-drug resistance 1 (MDR1), clinical parameters, prognosis and survival in MM patients treated with VAD (vincristine-adriamycine-dexamethason...

Journal: :Neuroscience and medicine 2013
Zishuo Ian Hu Ann Marie E Kotarba William E Van Nostrand

AIM The abnormal accumulation, assembly and deposition of the amyloid β-protein (Aβ) are prominent pathological features of patients with Alzheimer's disease (AD) and related disorders. A number of factors in the brain can influence Aβ accumulation and associated pathologies. The aim of the present study was to determine the consequences of deleting nitric oxide synthase (NOS) 3, the endothelia...

Journal: :REVISA 2022

Objetivo: O presente estudo analisou se a presença do polimorfismo VNTR localizado no íntron 4 gene NOS3 na região codante difere nos pacientes com Síndrome Metabólica e portadores de Hipertensão Arterial e/ou Diabetes Mellitus dos controles normotensos. Método: Neste caso-controle, foi executada técnica PCR para identificar genótipos em 94 idosas residentes Distrito Federal. As associações as ...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2014
Begoña Lavin Monica Gómez Oscar M Pello Borja Castejon Maria J Piedras Marta Saura Carlos Zaragoza

OBJECTIVE Nitric oxide synthase 3 (NOS3) prevents neointima hyperplasia by still unknown mechanisms. To demonstrate the significance of endothelial nitric oxide in the polarization of infiltrated macrophages through the expression of matrix metalloproteinase (MMP)-13 in neointima formation. APPROACH AND RESULTS After aortic endothelial denudation, NOS3 null mice show elevated neointima format...

2017
Linda S Pescatello Elizabeth D Schifano Garrett I Ash Gregory A Panza Lauren M L Corso Ming-Hui Chen Ved Deshpande Amanda Zaleski Burak Cilhoroz Paulo Farinatti Beth A Taylor Rachel J O'Neill Paul D Thompson

In previous studies, we found an endothelial nitric oxide synthase gene (NOS3) variant rs2070744 associated with the ambulatory blood pressure (BP) response following bouts of moderate and vigorous intensity acute exercise, termed post-exercise hypotension (PEH). In a validation cohort, we sequenced NOS3 exons for associations with PEH Obese (30.9 ± 3.6 kg.m-2) African American (n = 14) [AF] an...

2015
Zsolt Szelid Árpád Lux Márton Kolossváry Attila Tóth Hajnalka Vágó Zsuzsanna Lendvai Loretta Kiss Pál Maurovich-Horvat Zsolt Bagyura Béla Merkely Nir Eynon

Nitric oxide (NO), an important endogenous pulmonary vasodilator is synthetized by the endothelial NO synthase (NOS3). Reduced NO bioavailability and thus the Glu298Asp polymorphism of NOS3 may enhance right ventricular (RV) afterload and hypertrophic remodeling and influence athletic performance. To test this hypothesis world class level athletes (water polo players, kayakers, canoeists, rower...

Journal: :Circulation 2006
Rio Dumitrascu Norbert Weissmann Hossein Ardeschir Ghofrani Eva Dony Knut Beuerlein Harald Schmidt Johannes-Peter Stasch Mark Jean Gnoth Werner Seeger Friedrich Grimminger Ralph Theo Schermuly

BACKGROUND Severe pulmonary hypertension is a disabling disease with high mortality, characterized by pulmonary vascular remodeling and right heart hypertrophy. Using wild-type and homozygous endothelial nitric oxide synthase (NOS3(-/-)) knockout mice with pulmonary hypertension induced by chronic hypoxia and rats with monocrotaline-induced pulmonary hypertension, we examined whether the solubl...

One of the most striking features in autosomal dominant polycystic kidney disease (ADPKD) is the difference at onset age of end-stage renal disease (ESRD). Modifier genes may play a role in this phenotypic variability. The mutated nitric oxide synthase 3 gene (NOS3), have a modifier effect on the severity of ADPKD by impairment of NOS3 activity and decreasing of renal vascular nitric oxide prod...

Journal: :Human reproduction 2009
Hoon Kim Seung Yup Ku Sung Hoon Kim Gyoung Hoon Lee Young Min Choi Jong Mee Kim Taek Hoo Lee Shin Yong Moon

BACKGROUND Altered expression of endothelial nitric oxide synthase (eNOS) has been reported to be involved in the development of endometriosis. The genotypes of eNOS gene (NOS3) may be responsible for variation in its enzymatic activity as well as plasma concentration of nitric oxide. The Glu298Asp polymorphism of the NOS3 may modulate angiogenesis and influence individual susceptibility to end...

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