Background: In order to improve the evaluation of possible rectal toxicity based on the rectal normal tissue complication probability (NTCP), we consider the fractional dependence of the NTCP on the wall thickness (tW) and rectal displacement (RM). Materials and Methods: The two-dimensional NTCP model (NTCP2D) was developed using radiotherapy plans of ten randomly selected patients with prostat...

Classical models used in radiotherapy typically assume that after treatment all surviving cells have a constant and homogeneous sensitivity during the treatment period. In Keinj et al. (2010), a multinomial model based on a discrete-time Markov chain able to take into account both cell repair and cell damage heterogeneity due to radiations has been proposed. In this paper, we introduce the noti...

Introduction: Hypothyroidism is one of the frequent side effects of radiotherapy of head and neck cancers, breast cancer, and Hodgkin's lymphoma. It is recommended to estimate the normal tissue complication probability of thyroid gland using radiobiological modeling during treatment planning. Moreover, the use of artificial neural network is also proposed as a new method for t...

Radiotherapy efficacy is often limited by normal tissue toxicity. Standard models to estimate Normal Tissue Complication Probability (NTCP), such as Lyman-Kutcher-Burman (LKB), often rely on parameters derived from the dose-volume histograms (DVHs) which consider organs and tissues to be completely homogeneous with equal sub-volume radiation sensitivities. As a result, they neglect any potentia...