Lysophosphatidylcholine is the major lysophospholipid in mammalian tissues and has been shown to be cytolytic at high concentrations. In the present study we demonstrated that the level of lysophosphatidylcholine was significantly increased in the heart of rats fed with a vitamin E-deficient diet. Moreover, the cardiac lysophosphatidylcholine level was decreased in rats fed with a high vitamin ...

Several recent, reports from this laboratory have implicated vitamin E in the metabolism of the nucleic acids. It was shown that vitamin E-deficient rabbits excrete extra quantities of allantoin (1) and that the livers from such animals exhibit greatly increased xanthine oxidase activities (2). Finally it haa been shown that vitamin E deprivation in the rat, leads to an increased incorporation ...

At the time of its discovery two decades ago, vitamin E would have been defined as the fifth member of the then small family of vitamins. It was known to be widely distributed in green plants, in the germ of cereal grains, and, to a lesser extent, in animal tissues. It was known to be essential for normal reproduction in the laboratory rat. Although its ability to prevent fetal resorption in th...

Background: DZN (diazinon) is an organophosphate insecticide that had been used in agriculture and for domestic and veterinary use for several years and caused many negative effects on plants and animal species, especially on human. The aim of present study was to evaluate the effects of DZN on MDA (malondialdehyde) and GSH (glutathione) levels in female rat reproductive tissue (ovary) and to a...

Several recent, reports from this laboratory have implicated vitamin E in the metabolism of the nucleic acids. It was shown that vitamin E-deficient rabbits excrete extra quantities of allantoin (1) and that the livers from such animals exhibit greatly increased xanthine oxidase activities (2). Finally it haa been shown that vitamin E deprivation in the rat, leads to an increased incorporation ...

I . It has been suggested that carbon tetrachloride damages rat liver by accelerating processes of lipid peroxidation at subcellular sites and that the protective action of vitamin E is due to its functioning as an antioxidant in vivo. Direct evidence for these mechanisms in vivo has been sought and is critically examined. 2. The increased production of malondialdehyde by rat liver microsomal f...

OBJECTIVE This study compares the efficacies of vitamin E and selenium, both individually and in combination, for the prevention of postoperative intra-abdominal adhesions in rats. METHODS Forty-seven female rats were divided into five groups. The sham animals (S group, n = 7) were given only laparotomies and intraperitoneally received 0.9% NaCl (2 ml). In the 40 other rats, abrasions of the ...

BACKGROUND The goal of our study is to evaluate the effects of antioxidant vitamins (vitamin C and E), Coenzyme Q10 (CoQ10) and dexamethasone (Dxm) in experimental rat models with pulmonary contusion (PC). METHODS Rats were randomly divided into six groups. Except for the control, all subgroups had a moderate pulmonary contusion. Animals in the group I and group II received intraperitoneal sa...

Objective(s): In this study the effect of crocin, a carotenoid isolated from saffron, on malathion (an organophosphate insecticide) induced depressive- like behavior in subacute exposure was investigated. Moreover the molecular mechanism of malathion induced depressive- like behavior and its decreasing effect on the level of brain derived neurotrophic factor (BDNF) in rat hippocampus and cerebr...