Neuromyelitis Optica (NMO) is an autoimmune condition that predominantly targets optic nerves and spinal cord. The discovery of NMO-IgG and its target aquaporin-4 (AQP4) as a marker of NMO allowed a better understanding of the disease and, recently, a new definition and diagnostic criteria for NMO spectrum diseases (NMOSD) have been proposed [1]. In a subgroup of patients with NMOSD, a parainfe...

background: neuromyelitis optica spectrum disease (nmosd) is a severe autoimmune demyelinating disorder of the central nervous system that throughout epidemiological data, it has not been completely determined. the aim of this study was to assess characteristics of nmosd patients in isfahan as one of the most prevalent cities for multiple sclerosis in iran. materials and methods: forty-five pat...

BACKGROUND AND PURPOSE Neuromyelitis optica (NMO) is an idiopathic mostly relapsing inflammatory disease with attacks on the optic nerves and spinal cord. Whether NMO is a separate disease or a subtype of classic multiple sclerosis (MS) is unclear. Clinically, CSF and MR imaging parameters and histopathologic data suggest that the normal-appearing white matter (NAWM) may be affected in MS but n...

The astrocytic aquaporin-4 (AQP4) water channel is the target of pathogenic antibodies in a spectrum of relapsing autoimmune inflammatory central nervous system disorders of varying severity that is unified by detection of the serum biomarker neuromyelitis optica (NMO)-IgG. Neuromyelitis optica is the most severe of these disorders. The two major AQP4 isoforms, M1 and M23, have identical extrac...

Background: Neuromyelitis Optica (NMO) is an autoimmune inflammation of the central nervous system in which autoantibodies are released against Aquaporin-4 (AQP-4), astrocytic water channels. The disease is characterized by transverse myelitis and optic neuritis. Viruses could be inflammatory agents in the brain. Due to such inflammatory reactions, autoantibodies would cross the blood brain bar...

Objective: Aquaporin 4 (AQP4)-specific autoantibodies in neuromyelitis optica (NMO) are immunoglobulin (Ig)G1, a T cell-dependent Ig subclass, indicating that AQP4-specific T cells participate in NMO pathogenesis. Our goal was to identify and characterize AQP4-specific T cells in NMO patients and healthy controls (HC). Methods: Peripheral blood T cells from NMO patients and HC were examined for...

Neuromyelitis optica (NMO) is an inflammatory disorder of the central nervous system causing optic neuritis and transverse myelitis. NMO typically has a worse prognosis than multiple sclerosis due the severity of the acute relapses which lead significant visual and motor impairment. Although the discovery of an NMO-IgG or aquaporin-4 antibody has led to greater understanding about the pathophys...

Abstract Background Estradiol is an important marker of ovarian response to stimulation in ART cycles. The study tries find the correlation serum estradiol on day HCG trigger number follicles, oocytes retrieved, and mature oocytes, also, correlate per follicle oocyte HCG, oocytes. It a cross sectional using retrospective data. Results data 232 patients were analyzed. Our showed positive between...

BACKGROUND Neuromyelitis optica (NMO) is an uncommon neuro-inflammatory syndrome that has shown to be distinct from multiple sclerosis (MS) and associated with the autoantibody marker NMO-immunoglobulin G (IgG). There are still only a few studies regarding the epidemiology of NMO in Iran. In the present study, we tried to describe the epidemiology of NMO in Khuzestan as one of the densely popul...