Progress toward understanding the function and regulation of noncoding RNAs is the topic of this issue's Molecular Biology Select. Recent reports provide mechanistic insight into the regulation of transcription by noncoding RNAs found at gene promoters. Other findings reveal a new mechanism for the regulation of attenuated noncoding transcripts, provide evidence for the involvement an antisense...

Noncoding RNA Scaffolds in Pluripotency Print ISSN: 0009-7330. Online ISSN: 1524-4571 Copyright © 2012 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation Research doi: 10.1161/RES.0b013e318257c489 2012;110:1162-1165 Circ Res. http://circres.ahajournals.org/content/110/9/1162 World Wide Web at...

It is acknowledged that postnatal mammalian cardiomyocytes (CMs) turn over with a very limited efficacy in both physiological and pathological conditions. Recent studies showed that those newly formed CMs are derived from preexisting CMs. Thus, stimulating CM proliferation becomes a promising strategy for inducing cardiac regeneration. Noncoding RNAs were found differently expressed in CMs with...

Transcription occurs across more than 70% of the human genome and half currently annotated genes produce functional noncoding RNAs. Of these transcripts, majority—long, RNAs (lncRNAs)—are greater 200 nucleotides in length are necessary for various roles cell. It is increasingly appreciated that lncRNAs relevant both health disease states, with brain expressing largest number compared to other o...