The systemic administration of oncolytic virus (OV) is often inefficient due to clearance of the virus by host defense mechanism and spurious targeting of non-cancer tissues through the bloodstream. Cell mediated OV delivery could hide the virus from host defenses and direct them toward tumors: Mesenchymal and neural stem cells have been described to possess tumor-homing ability as well as the ...

objective(s): although viral vectors are considered efficient gene transfer agents, their board application has been limited by toxicity, immunogenicity, mutagenicity and small gene carrying capacity. non-viral vectors are safe but they suffer from low transfection efficiency. in the present study, polyallylamine (paa) in two molecular weights (15 and 65 kda) was modified by alkane derivatives ...

In this paper, a numerical study of barrier characterization effects on the high-temperature internal performance of an InGaAsP multi-quantum well laser is presented. The softwareused for this purpose self-consistently combines the three-dimensional simulation of carrier transports, self-heating, and optical waveguiding. The laser model calculates all relevant physical mechanisms, including the...

amphiphilic cationic micelles have recently attracted much attention as non-viral vector. in the current study the retinoic acid-g-chitosan (ra-chitosan) micelles have been used as novel gene carriers. uptake of micelles, condensation ability and transfection efficiency of micelle–dna complexes (miceplexes) in the presence or absence of serum had been investigated on hela and hepg2 cell lines. ...

Recognition of viral glycans by pattern recognition receptors (PRRs) in innate immunity contributes to antiviral immune responses. C-type lectin receptors (CLRs) are PRRs capable of sensing glycans present in viral pathogens to activate antiviral immune responses such as phagocytosis, antigen processing and presentation, and subsequent T cell activation. The ability of CLRs to elicit and shape ...