Background: The most frequently mutated tumor suppressor gene found in human cancer is p53. In a normal situation, p53 is activated upon the induction of DNA damage to either arrest the cell cycle or to induce apoptosis. However, when mutated, p53 is no longer able to properly accomplish these functions. The aim of this study was to investigate the expression of p53 gene in cases of skin cancer...

BACKGROUND Pilot studies have estimated cancer incidence in patients with systemic lupus erythematous (SLE). However, the results have been inconclusive. To ascertain the correlation between SLE and malignancy more comprehensively and precisely, we conducted a meta-analysis. METHODS PubMed, the Cochrane Library and Embase databases through June 2014, were searched to identify observational st...

Ultraviolet radiation (UVR) has been identified as the primary etiologic agent for the induction and promotion of most skin cancers. The first associations between solar UVR and skin cancer were acknowledged by the scientific community in 1927. Since then, increasing evidence for the role of UVR in the causation of skin cancer has resulted in the listing of solar and artificial UVR as a human c...

AIMS To provide the first single-center study of a Czech renal transplant program that compares skin cancer risk estimates to the general population. METHODS We studied a total of 603 patients undergoing renal transplantation at the University Hospital Olomouc Transplant Center between January 1984 and December 2009. The mean time of follow-up was 5.5 years. Three patients were excluded for s...

Skin cancer is the most common type of cancer in the United States, with an increasing annual rate. Defining the mechanism of skin cancer malignancy and progression is the first step towards skin cancer prevention and therapy. “Warburg Effect” describes the preference of glycolysis and lactate fermentation rather than oxidative phosphorylation for energy production in cancer cells, which also p...

BACKGROUND Melanoma is the major cause of skin cancer death worldwide. Parkinson's disease is a neurodegenerative disorder that is caused by mutation of alpha-synuclein or other genes. Importantly, epidemiological studies have reported co-occurrence of melanoma and Parkinson's disease, suggesting that these two diseases could share common genetic components. METHODOLOGY/PRINCIPAL FINDINGS Rec...

Background: Malignant melanoma is the most aggressive form of skin cancer. In contrast to other tumors, the role of estrogen in the initiation and progression of melanoma remains unclear. The aim of this study was to evaluate estrogen receptor beta protein expression in human melanoma tissues and in the benign melanocytic lesions. Method: Twenty-one patients, 11 with cutaneous melanoma and 10 w...

Skin cancer has a significant impact on the health care system of many societies. The most common types of skin cancer are Non-Melanoma Skin Cancer (NMSC) and melanoma. In the United States, NMSC incidence is greater than all other cancers combined. Although death is a rare outcome of NMSC, recurrence is fairly common. In contrast, melanoma is highly metastatic, chemoresistant and is often leth...

Dermatological malignancies, such as skin cancer, are the most extensively known kinds of human malignancies in people with fair skin. Despite fact that malignant melanoma is type cancer associated highest mortality rate, non-melanoma tumors unquestionably normal. The frequency both and cancers increasing, number cases being studied increasing at a reasonably regular period, according to Nation...

On the roles of skin type and sun exposure in the risk of endometriosis and melanoma The recent paper by Kvaskoff et al. 1 reported observations of endometriosis risk in relation to naevi, freckles and skin sensitivity to sun exposure. The study found significantly increased risk for endome-triosis for those highly sensitive to sun exposure and for those with naevi or freckles. Those with dark ...