Malaria is among the factors thought to be involved in the pathogenesis of endomyocardial fibrosis (EMF), a restrictive cardiomyopathy of unclear etiology, with no specific therapy, which affects predominantly children and adolescents. In Africa, regions endemic with EMF are also areas with high prevalence of malaria. We studied 47 consecutive children aged 5- to 15-years old and concluded that...

A major manifestation of complicated malaria especially among children is severe anaemia, the pathogenesis of which is not well understood. Among other factors, suppression of the bone marrow's response to erythropoietin, which is rapidly reversed after successful treatment of the malaria, has been implicated in its pathogenesis. Since resolution of malaria restores erythropoiesis, we hypothesi...

Although malaria is widely considered a major cause of death in young children born with sickle cell anemia (SCA) in sub-Saharan Africa, this is poorly quantified. We attempted to investigate this question through 4 large case-control analyses involving 7164 children living on the coast of Kenya. SCA was associated with an increased risk of admission to hospital both with nonmalaria diseases in...

Severe (complicated) malaria caused by Plasmodium falciparum kills over a million people every year. The annual death toll can be as high as one in 100 children under the age of five(1). Intravenous infusion of quinine is recommended as an initial therapy for these children. Recent years have witnessed increasing use of artemisinin derivatives (mainly artesunate) in the treatment of severe mala...

Malaria is an important treatable cause of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) in the tropics and in the returning traveller in the non-endemic areas. ARDS is an important complication in severe, complicated falciparum malaria and has been described in P. vivax and P. ovale malaria also. Malarial ALI/ARDS is more common in adults than in children. Pregnant wom...

Malaria is an infectious protozoan parasitic disease transmitted by Anopheles spp mosquito. As a entity, malaria still major global health problem due to its morbidity and mortality that endangered millions of individuals inhabitants in tropical region. Kidney derangement moderately frequent severe caused the species P. falciparum also malariae, but seldom this condition has been reported vivax...

evaluation of a malaria screening program was carried out in two screened afghan refugee camps in bardsir and rafsanjan and compared to non-screened afghan refugees within kerman, as well as refugees with malaria diagnosed by communicable disease control (cdc) laboratories in kennan and rafsanjan, by parasitological blood examinations. the study involved 456 residents of two refugee camps and r...

s ................................................................................................................................................................. p. 31 Author index ........................................................................................................................................................... p. 122 General information ..................................

BACKGROUND Mannose binding lectin, a plasma protein protects host from virus, bacteria, and parasites. Deficiency in MBL levels has been associated with susceptibility to various infectious diseases including P. falciparum malaria. Common MBL polymorphisms in promoter and coding regions are associated with decrease in plasma MBL levels or production of deformed MBL, respectively. In the present...