Knowledge of the energetics of the low solubility of non-polar compounds in water is critical for the understanding of such phenomena as protein folding and biomembrane formation. Solubility in water can be considered as one leg of the three-part thermodynamic cycle - vaporization from the pure liquid, hydration of the vapor in aqueous solution, and aggregation of the substance back into initia...

Chemical kinetics, also known as reaction kinetics, is the study of chemical processes’ rates. Chemical kinetics includes investigations into how different experimental conditions can influence the speed of a chemical reaction, and yield information about the reaction's mechanism and transitional states, as well as the construction of mathematical models that can describe the characteristics of...

The solubility of disodium terephthalate in aqueous sodium hydroxide and hydroxide–ethylene glycol mixtures was determined experimentally by temperature analysis, gravimetry titration. experimental results were compared with existing literature data the phase diagrams from −25 to 70 °C. has no considerable dependence on temperature. freezing points solutions vary composition like any other solu...

lentiviral vectors (lvs) are useful vehicle for genetransfer to dividing and non-dividing cells and genetic manipulations. however, the use of lentiviruses in studies requires an accurate titration technique.quantitative real-time pcr (qpcr) is a sensitive technique for the indication and quantitation of retrovirals particles. in this study, we used the qpcr for lentiviral vector titeration. th...

The helical stability of poly-L-glutamic acid and poly-Lornithine in aqueous alcohol solutions was studied by optical rotatory dispersion and potentiometric titration determinations. It was found that aliphatic alcohols enhance the stability of the helix according to the series methanol < ethanol < I-propanol < I-butanol. The role of secondary and tertiary alcohols was also investigated. Thermo...

The objective of this study was to design and develop o/w microemulsion for transdermal delivery of poorly water soluble acyclovir by aqueous titration method. Oleic acid: castor oil (3:1), tween 80, and ethanol were selected as oily phase, surfactant and cosurfactant respectively. The Pseudoternary phase diagrams were constructed by aqueous titration method. The cosurfactant affect the shape a...

Potentiometric titration in non-aqueous media is a standard method for the determination of the basicity and acidity of various compounds, particularly in organic and pharmaceutical analyses. The reason for using non-aqueous solvents is that many organic compounds of pharmaceutical importance do not dissolve in water. Furthermore, since water is amphoteric, only a limited range of acid and base...

2D 1H-15N HMBC NMR acquired at natural abundance and DMSO titration monitored by 1D 1H NMR verified the existence of an intramolecular hydrogen bond that was designed to mimic the pyrimidinone ring of a class of kinase inhibitors. A scalar coupling across the hydrogen bond was detected in organic and aqueous solvent, suggesting a simple and general approach for testing the propensity of intramo...

Highly nonexponential folding kinetics in aqueous solution have been observed during temperature jump-induced refolding of two proteins, yeast phosphoglycerate kinase and a ubiquitin mutant. The observations are most easily interpreted in terms of downhill folding, which posits a heterogeneous ensemble of structures en route to the folded state. The data are also reconciled with exponential kin...

The Mobile Insulin Titration Intervention (MITI) for Insulin Glargine Titration in an Urban, Low-Income Population: Randomized Controlled Trial TITLE 1a-i) Identify the mode of delivery in the title Yes, the study uses mobile phones. "The Mobile Insulin Titration Intervention (MITI) for Insulin Glargine Titration in an Urban, Low-Income Population: Randomized Controlled Trial" 1a-ii) Non-web-ba...