Recent studies in mice have identified single molecules that can delay multiple diseases of aging and extend lifespan. In theory, such molecules could prevent dozens of diseases simultaneously, potentially extending healthy years of life. In this review, we discuss recent advances, controversies, opportunities, and challenges surrounding the development of SIRT1 activators, molecules with the p...

Abstract The use of antibiotics for the control infections has not only been banned by FDA in food-producing animals, but also several countries have prohibited their aquaculture because reasons such as occurrence antibiotic-tolerant microorganisms, accumulation antibiotic residues fish and shrimp flesh, aquatic environmental effluence concerns. These issues led researchers scientists to conduc...

The use of both over-the-counter and prescription nonsteroidal medications is frequently recommended in a typical neurosurgical practice. But persistent long-term use safety concerns must be considered when prescribing these medications for chronic and degenerative pain conditions. This article is a literature review of the biochemical pathways of inflammatory pain, the potentially serious side...

AIM To recognize a line of treatment for scleredema of Buschke in an adolescent. BACKGROUND Scleredema of Buschke is an uncommon disorder characterized by induration of the skin, which includes a non pitting hardening of the skin around the neck, shoulders, and trunk sometimes the face. Three variants are recognized. The histopathologic features of scleredema are characterized by thickened co...

this experiment was conducted to investigate the effect of antibiotic, organic acid, probiotic and prebiotic on quality traits of eggs, egg yolk lipids and blood metabolites of laying hens strain hy-line (w-36). the experiment was carried out as a completely randomized design from 32 to 42 weeks of age with 5 treatments, 4 replicates and 8 hens in each replicate. the experimental treatments con...

background : uncontrolled and irrational use of antibiotics increases the rate of antimicrobial resistance and treatment failure. compliance with antibiotics is an important indicator to show how patients use their prescribed drugs and it can explain the relationship between drug administration and treatment outcome that needs to be monitored and promoted. we decided to evaluate compliance to a...