OBJECTIVE Research on placebo/nocebo effects suggests that expectations can influence treatment outcomes, but placebo/nocebo effects are not always evident. This research demonstrates that a provider's social behavior moderates the effect of expectations on physiological outcomes. METHODS After inducing an allergic reaction in participants through a histamine skin prick test, a health care pr...

Throughout history, patient-physician relationships have been acknowledged as an important component of the therapeutic effects of any pharmacological treatment. Here, we discuss the role of physicians' expectations in influencing the therapeutic outcomes of alcohol and drug addiction pharmacological treatments. As largely demonstrated, such expectations and attitudes may contribute to produce ...

BACKGROUND This study was designed to compare placebo responses in men and women. METHODS Data for 501 women and 375 men with major depressive disorder treated with placebo from seven investigational randomized double-blind trials comparing fluoxetine with placebo were analyzed. Changes in major depressive disorder symptoms with placebo administration were measured as changes in total Hamilto...

Abstract Background: Motor learning (ML) can be defined as “any experience-dependent improvement in performance”. Behavioral evidence showed that placebo and nocebo modulate ML, but the neurophysiological underpinnings influence of their effect on implicit processes are still unknown. Objective: The aim this study is to understand if how manipulations could probabilistic sequence explore whethe...

Among patients receiving interventions for pain, the role of nonspecific treatment effects on their outcomes has been the subject of much interest and controversy. Placebo and nocebo effects are widely seen in medicine and biology; however, their underlying psychological and neurobiological mechanisms are only beginning to be more fully understood. Placebo analgesia occurs when a non-analgesic ...