Background and Objective: Recent studies have shown that anticholinergic alkaloids compounds have strong analgesic effects. Due to presence of anticholinergic alkaloids in Hyoscyamus niger and its mentioned effects in Iranian traditional medicine, its analgesic effects were assessed. At first, acute and chronic pain thresholds in male NMRI rats with formalin test was evaluated, then oral and in...

Ficoll-purified lymphocytes (peritoneal, splenic, or thymic) and macrophages (peritoneal) from Toxoplasma-immune and normal female NMRI mice were used. Suspensions of washed cells were made in medium 199 containing 20% heat-inactivated normal calf serum. Sixty minutes after the adherence of 10(5) macrophages to cover slips in Leighton tubes, lymphocytes were added in various concentrations. The...

The highly mutagenic heterocyclic amines, 2-amino-3-methylimidazo[4,5-nquinoline (IQ) and 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MelQ), are formed during heating of pro tein-rich foods. In order to gain information about the distribution and fate of IQ and MelQ in vivo, a whole-body autoradiographic study of i.v.-injected 14C-labeled IQ and MelQ has been per formed in male NMRI, pregnant ...

BACKGROUND As previously various studies have suggested application of brain-derived neurotrophic factor (BDNF) may be considered as a promising future therapy for hearing deficits, in particular for the improvement of cochlear neurone loss during cochlear implantation. AIM The present study's aim was to establish the upper threshold of the concentration of BDNF in Naval Medical Research Inst...

BACKGROUND This investigation aimed to evaluate the in vitro scolicidal effects of Pistacia khinjuk methanolic extract against protoscoleces of hydatid cysts and its acute toxicity in mice NMRI model. METHODS Protoscoleces were aseptically extracted from sheep livers having hydatid cysts. Various concentrations of the essential oil (12.5-100 mg/mL) were used for 10 to 60 min. Viability of pro...

BACKGROUND Over the past several years, mammals have been successfully cloned by either the splitting of an early stage embryo or nuclear transfer of adult somatic cells (NT) into oocytes. Although it has been 15 years since the generation of the first cloned mammals from somatic cells by NT, the success rate for producing live offspring by this technique is low regardless of the cell type and ...

Interactions between early developing Schistosoma mansoni larval stages and the hemolymph of its snail intermediate host represent the first molecular encounter with the snail's immune system. To gain a more comprehensive understanding of this early parasite-host interaction, biotinylated sporocyst tegumental membrane (Mem) proteins and larval transformation proteins (LTP) were affixed to strep...