نتایج جستجو برای: nm
تعداد نتایج: 125868 فیلتر نتایج به سال:
We investigated the viscoelastic response of model interphase chromosomes by tracking the three-dimensional motion of hundreds of dispersed Brownian particles of sizes ranging from the thickness of the chromatin fiber up to slightly above the mesh size of the chromatin solution. In agreement with previous computational studies on polymer solutions and melts, we found that the large-time behavio...
Each of the core histone proteins within the nucleosome has a central "structured" domain that comprises the spool onto which the DNA superhelix is wrapped and an N-terminal "tail" domain in which the structure and molecular interactions have not been rigorously defined. Recent studies have shown that the N-terminal domains of core histones probably contact both DNA and proteins within the nucl...
We use spatially resolved photoelectron spectroscopy performed in operando to identify the reaction intermediates of the hydrogen electro-oxidation reaction on yttria-stabilized zirconia (YSZ) electrolytes with Pt electrodes. We find that hydroxyl on the zirconia electrolyte is a reaction intermediate in the hydrogen oxidation reaction and that it participates in the rate-determining step. In c...
The basic and intrinsically disordered C-terminal domain (CTD) of the linker histone (LH) is essential for chromatin compaction. However, its conformation upon nucleosome binding and its impact on chromatin organization remain unknown. Our mesoscale chromatin model with a flexible LH CTD captures a dynamic, salt-dependent condensation mechanism driven by charge neutralization between the LH and...
Recent results in living cells have now established the existence of levels of chromatin folding above the 30 nm fiber within interphase chromosomes. We discuss the potential functional impact of this large-scale chromatin organization, including its possible role in regulating gene expression.
Genomes are more than linear sequences. In vivo they exist as elaborate physical structures, and their functional properties are strongly determined by their cellular organization. I discuss here the functional relevance of spatial and temporal genome organization at three hierarchical levels: the organization of nuclear processes, the higher-order organization of the chromatin fiber, and the s...
The structure of the nucleosome, the basic building block of the chromatin fiber, plays a key role in epigenetic regulatory processes that affect DNA-dependent processes in the context of chromatin. Members of the HMGN family of proteins bind specifically to nucleosomes and affect chromatin structure and function, including transcription and DNA repair. To better understand the mechanisms by wh...
We describe an approach to detect the frequency of interaction between any two genomic loci. Generation of a matrix of interaction frequencies between sites on the same or different chromosomes reveals their relative spatial disposition and provides information about the physical properties of the chromatin fiber. This methodology can be applied to the spatial organization of entire genomes in ...
با بزرگ شدن ابعاد شبکه قدرت و تقاضای روز افزون مصرف الکتریکی در این شبکه شاهد نوسانات شدید فرکانس بوده و به دنبال آن به دلیل عدم کنترل دقیق فرکانس در سالهای اخیر با پدیده خاموشی رو به رو بوده ایم. بنابراین، لازم است که کنترلی طراحی گردد که فرکانس سیستم و قدرت خطوط ارتباطی بین نواحی را درنزدیکترین مقدار برنامه ریزی شدهی ممکن نگاه دارد. این عمل، کنترل فرکانس- بار سیستم نام گذاری می شود. مطالعات ب...
enterohemorrhagic escherichia coli (ehec) of the o157:h7 serotype is a worldwide zoonotic pathogen responsible for the majority of severe cases of human ehec disease. the aim of the present study was to investigate the prevalence of e. coli o157: h7/nm in raw meat samples from two provinces of iran. during a period from march 2010 to march 2011. two hundred and ninety five raw meat samples were...
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