نتایج جستجو برای: nk cytotoxicity

تعداد نتایج: 63985  

Journal: :British journal of anaesthesia 2003
A J Cronin N M Aucutt-Walter T Budinetz C P Bonafide N A DiVittore V Gordin H G Schuler R H Bonneau

BACKGROUND Mu opioid agonists suppress natural killer (NK) cell activity in animal models. Studies in human volunteers, however, have yielded conflicting results, with morphine suppressing and fentanyl increasing NK cell activity. This study evaluated the effect of a constant 8-h infusion of remifentanil on NK cell number and function in human volunteers. METHODS After IRB approval and inform...

Journal: :The Journal of Experimental Medicine 1996
Nicholas M. Valiante Joseph H. Phillips Lewis L. Lanier Peter Parham

The killer cell inhibitory receptors (KIR) of human natural killer (NK) cells recognize human leukocyte antigen class I molecules and inhibit NK cell cytotoxicity through their interaction with protein tyrosine phosphatases (PTP). Here, we report that KIR recognition of class I ligands inhibits distal signaling events and ultimately NK cell cytotoxicity by blocking the association of an adaptor...

Journal: :Journal of immunology 2013
Ana Sofia Cerdeira Augustine Rajakumar Caroline M Royle Agnes Lo Zaheed Husain Ravi I Thadhani Vikas P Sukhatme S Ananth Karumanchi Hernan D Kopcow

NK cells that populate the decidua are important regulators of normal placentation. In contrast to peripheral blood NK cells, decidual NK (dNK) cells lack cytotoxicity, secrete proangiogenic factors, and regulate trophoblast invasion. In this study we show that exposure to a combination of hypoxia, TGF-β1, and a demethylating agent results in NK cells that express killer cell Ig-like receptors,...

2011
Louisa Kühne Mathias Konstandin Yvonne Samstag Stefan Meuer Thomas Giese Carsten Watzl

The redox-active chlorite-based drug WF10 (Immunokine) was shown to have modulatory effects on both the innate and adaptive immune system in vitro and in vivo. Animal studies suggest that WF10 enhances immunity against tumors. One possible explanation for such an effect is that WF10 stimulates natural killer cell cytotoxicity against malignant cells. Here, we show that WF10 regulates human NK c...

Journal: :Cancer immunology research 2014
Phyllis F Y Cheung Chi Wai Yip Nicholas C L Wong Daniel Y T Fong Linda W C Ng Angus M Y Wan Chun Kwok Wong Tan To Cheung Irene O L Ng Ronnie T P Poon Sheung Tat Fan Siu Tim Cheung

Immunoevasion is an emerging hallmark of cancer. Impairment of natural killer (NK) cytotoxicity is a mechanism to evade host immunosurveillance. Granulin-epithelin precursor (GEP) is a hepatic oncofetal protein regulating growth, invasion, and chemoresistance in hepatocellular carcinoma (HCC). We examined the role of GEP in conferring HCC cells the ability to evade NK cytotoxicity. In HCC cell ...

2013
Katrin S. Reiners Jörg Kessler Maike Sauer Achim Rothe Hinrich P. Hansen Uwe Reusch Christian Hucke Ulrike Köhl Horst Dürkop Andreas Engert Elke Pogge von Strandmann

Natural killer (NK) cells represent a key component of the innate immune system against cancer. Nevertheless, malignant diseases arise in immunocompetent individuals despite tumor immunosurveillance. Hodgkin lymphoma (HL) is characterized by CD30(+) tumor cells and a massive infiltration of immune effector cells in affected lymph nodes. The latter obviously fail to eliminate the malignant cell ...

Journal: :International immunology 2009
Gareth J Jones Jeremy C D Wiseman Kaleb J Marr Sheng Wei Julie Y Djeu Christopher H Mody

NK cell cytotoxicity requires two positive signals for killing of tumors. Activation receptors induce polarization of the microtubule organization center and degranulation, while leukocyte function-associated antigen (LFA)-1 is required for conjugate formation and actin polymerization and under some circumstances may be sufficient for NK cell cytotoxicity. Although the receptor for direct killi...

Journal: :Blood 2015
Fernando E Sepulveda Sophia Maschalidi Christian A J Vosshenrich Alexandrine Garrigue Mathieu Kurowska Gael Ménasche Alain Fischer James P Di Santo Geneviève de Saint Basile

The impairment of cytotoxic activity of lymphocytes disturbs immune surveillance and leads to the development of hemophagocytic lymphohistiocytic syndrome (HLH). Although cytotoxic T lymphocyte (CTL) control of HLH development is well documented, the role for natural killer (NK)-cell effector functions in the pathogenesis of this immune disorder remains unclear. In this study, we specifically t...

Journal: :Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005
Susan K Lutgendorf Anil K Sood Barrie Anderson Stephanie McGinn Heena Maiseri Minh Dao Joel I Sorosky Koen De Geest Justine Ritchie David M Lubaroff

PURPOSE Psychosocial stress has been related to impaired immunity in cancer patients. However, the extent to which these relationships exist in immune cells in the tumor microenvironment in humans has not been explored. We examined relationships among distress, social support, and natural killer (NK) cell activity in ovarian cancer patients in peripheral-blood mononuclear cells (PBMC), ascitic ...

2015
Phyllis FY Cheung Chi Wai Yip Linda WC Ng Chun Kwok Wong Tan To Cheung Chung Mau Lo Sheung Tat Fan Siu Tim Cheung

Impairment of natural killer (NK) cell activity is an important mechanism of tumor immunoevasion. We have previously shown that expression of granulin-epithelin precursor (GEP) in hepatocellular carcinoma (HCC) cells rendered the cells resistant to NK cell immunosurveillance. Here, we examined whether targeting GEP could rescue NK activity in HCC patients. The current study demonstrated that qu...

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