Galectin-9 is a b-galactoside binding lectin with expressed immunoregulatory activity. During pregnancy galectin-9 produced by trophoblast cells and regulates the function of natural killer (NK) at maternal-fetal interface via to Tim-3 (T-cell Ig mucin domain-containing protein 3) molecules. Natural lymphocytes belong innate lymphoid cells, which have cytotoxic effect on target are capable prod...

Background: The mammalian target of rapamycin (mTOR) is important in hematopoiesis. Despite the central role of mTOR in regulating the differentiation of immune cells, the effect of mTOR function on cord blood mononuclear cells is yet to be defined. Objectives: To evaluate the effect of mTOR inhibition, using rapamycin on the proliferation and apoptosis of cord blood mononuclear cells, as well ...

objective: adipose derived stem cells (ascs), as one of the important stromal cells in the tumor microenvironment, are determined with immunomodulatory effects. the principle aim of this study was to evaluate the immunosuppressive effects of ascs on natural killer (nk) cells. materials and methods: in this experimental study, we assessed the expressions of indolamine 2, 3-dioxygenase (ido1), id...

Abstract Natural killer (NK) cells have been implicated in Ebola virus disease (EVD) pathogenesis as well protection against viruses. A clear understanding of their role during EVD is needed for better exploiting functionalities designing effective countermeasures Previously, we reported that protein VP40 induces IL-12 and IL-18 dependent activation human NK involves accessory cells. Here, exte...

To systematically define molecular features in human tumor cells that determine their degree of sensitivity to allogeneic natural killer (NK) cells, we quantified the NK cell responsiveness hundreds molecularly annotated ‘DNA-barcoded’ solid lines multiplexed format and applied genome-scale CRISPR-based gene-editing screens several lines, functionally interrogate which genes regulate response c...