Sézary syndrome (SS) is a rare, leukemic type of cutaneous T-cell lymphoma (CTCL), for which extracorporeal photopheresis (ECP) first-line therapy. Reliable biomarkers to objectively monitor the response ECP in patients with SS are missing. We examined quantitative and qualitative impact on natural killer (NK) cell activity patients, especially their functional ability antibody-dependent cell-m...

Natural Killer(NK) cell nenoplasm is heterogeneous disease group. In the latest World Health Organization(WHO) classification of tumors of hematopoietic and lymphoid tissue(2008), disease entities considered as NK cell deviation are 1) Aggressive NK cell leukemia (ANKL), 2) NK cell lymphoblastic leukemia/lymphoma, 3) Extranodal NK/T-cell lymphoma, nasal. While several NK related diseases are pr...

PURPOSE Renal cell carcinoma harbors high numbers of infiltrating lymphocytes with apparent limited efficacy in tumor control. This study focused on the natural killer (NK) cells infiltrating renal cell carcinoma. EXPERIMENTAL DESIGN Tumor-infiltrating lymphocytes (TIL) were isolated from renal cell carcinoma and analyzed for NK cell frequency and phenotype (n = 34). NK cells were enriched an...

Abstract Natural killer (NK) cells have been implicated in Ebola virus disease (EVD) pathogenesis as well protection against viruses. A clear understanding of their role during EVD is needed for better exploiting functionalities designing effective countermeasures Previously, we reported that protein VP40 induces IL-12 and IL-18 dependent activation human NK involves accessory cells. Here, exte...

SummarySézary syndrome (SS) is a rare, leukemic type of cutaneous T-cell lymphoma (CTCL), for which extracorporeal photopheresis (ECP) first-line therapy. Reliable biomarkers to objectively monitor the response ECP in patients with SS are missing. We examined quantitative and qualitative impact on natural killer (NK) cell activity patients, especially their functional ability antibody-dependent...

In humans, NK cells are mainly identified by the surface expression levels of CD56 and CD16, which differentiate between five functionally different NK cell subsets. However, nowadays NK cells are considered as a more heterogeneous population formed by various subsets differing in function, surface phenotype, and anatomic localization. In human CMV- and hantaviruses-infected subjects, an increa...

Galectin-9 is a b-galactoside binding lectin with expressed immunoregulatory activity. During pregnancy galectin-9 produced by trophoblast cells and regulates the function of natural killer (NK) at maternal-fetal interface via to Tim-3 (T-cell Ig mucin domain-containing protein 3) molecules. Natural lymphocytes belong innate lymphoid cells, which have cytotoxic effect on target are capable prod...

The literature suggests that effective defence against tumour cells requires contributions from both Natural Killer (NK) and CD8+ T cells. NK are spontaneously active infected target cells, whereas take some times to activate cell called as cell-specific targeting, kill the virus. interaction between has produced other cell, tumour-specific We illustrate tumour–immune through mathematical model...

NK cell development is far less understood compared with that of T and B cells despite the critical importance of NK cells in innate immunity. Mice lacking the transcription factor IFN regulatory factor-2 (IRF-2) are known to exhibit NK cell deficiency. However, the role of IRF-2 in NK cell development has remained unclear. In this study we found that NK cell deficiency in the periphery in IRF-...