BACKGROUND Within the intensive-care unit, non-invasive ventilation (NIV) can prevent the need for intubation and the mortality associated with severe episodes of chronic obstructive pulmonary disease (COPD). The aim of this study was to find whether the introduction of NIV, early after the admission on a general respiratory ward, was effective at reducing the need for intubation and the mortal...

BACKGROUND Our objective was to evaluate the feasibility, the quality of synchronization, and the influence on respiratory parameters of the noninvasive neurally adjusted ventilatory assist (NIV-NAVA) mode in infants after cardiac bypass surgery. We conducted a prospective, randomized cross-over study in infants undergoing noninvasive ventilation (NIV) after cardiac surgery. METHODS Subjects ...

The use of noninvasive ventilation (NIV) in acute hypercapnic respiratory failure, cardiogenic pulmonary oedema, acute lung injury/acute respiratory distress syndrome (ARDS), community-acquired pneumonia and weaning/post-extubation failure is considered common in clinical practice. Herein, we review the use of NIV in unusual conditions. Evidence supports the use of NIV during fibreoptic broncho...

The genes for Nipah virus (NiV) proteins were amplified from viral RNA, cloned into the plasmid pTriEx-3 Hygro, expressed, and purified using immobilized metal affinity chromatography. The recombinant N, F, and G NiV proteins (rNiV-N, rNiV-F, and rNiV-G), were successfully expressed in Escherichia coli and purified with a yield of 4, 16, and 4 mg/L, respectively. All 3 recombinant viral protein...

Methods We conducted a retrospective care note analysis of all patients receiving their first NIV period at any time during their ICU admission between 1 January 2014 and 31 December 2014. Patients receiving NIV after a period of mechanical ventilation were excluded from this analysis. Patients were analysed depending on whether they received NIV for a total period of < 48 hours or > 48 hours. ...

Objectives Noninvasive ventilation (NIV) is considered the standart of care in the management of acute hypercapnic respiratory failure due to COPD. NIV failure has been defined as the need for endotracheal intubation or death. Its rate greatly varies between 5-60%, depending on numerous factors. The choice of interface during NIV represents the main determinant of its success in an acute settin...

Objective: To determine if children intubated after failed Noninvasive Ventilation (NIV) have a higher occurrence of Tracheal Intubation Associated Events (TIAEs) compared to those intubated immediately. Methods: We conducted a retrospective study of all Tracheal Intubations (TIs) in a tertiary pediatric intensive care unit from 1/2013 to 12/2015. Data were collected from National Airway Regist...

The literature supporting the use of noninvasive ventilatory support (NIV) in acute respiratory failure has markedly increased over the last 20 years.1-3 Most would now consider NIV as first line therapy in the treatment of COPD exacerbations, cardiogenic pulmonary edema, and acute hypoxemic respiratory failure in a variety of settings.1-3 The vast majority of the literature supporting the use ...

The use of noninvasive ventilation (NIV) for acute respiratory failure has become widespread, but with the newfound beneficial treatments come complications. There is credible although somewhat disparate evidence to support the concept that, compared to invasive ventilation, NIV can reduce the incidence of infectious complications. In selected populations, nosocomial pneumonia appears to be sig...

Noninvasive ventilation (NIV) has assumed an important role in the management of certain types of respiratory failure in acute-care hospitals. However, the optimal location for NIV has been a matter of debate. Some have argued that all patients begun on NIV in the acute-care setting should go to an intensive care unit (ICU), but this is impractical because ICU beds are often unavailable, and it...