Background: Unintentional drug intoxication is still a major cause of mortality and morbidity in young children. Method & Materials: In order to study changes of epidemiological indices of children intoxication during a 10-year period in Hamadan Province, all cases admitted to Ghaem Hospital from 1995-1999 were recruited, and compared with all cases admitted to the same hospital from 1990-1...

Data regarding the role of oxygen in nitrite reduction are presented. In an NADPH-generating system including homogeneously purified ferredoxin-NADP reductase, ferredoxin (or flavodoxin) and nitrite reductase from the alga Bumilleriopsis filiformis, oxygen and nitrite can be reduced simultaneously. In air, rates of 1.2 mumol nitrite reduced-min-1-mg-1 nitrite reductase are obtained, which are p...

Like the nitrate transport system, the nitrite uptake system in Neurospora crassa is induced by either nitrate or nitrite. This induction is prevented by cycloheximide, puromycin, or 6-methyl purine. The K(m) for nitrite of the induced nitrite uptake system is 86 muM, and the V(max) is 100 mumol of nitrite per g (wet weight) per h. Nitrite uptake is inhibited by metabolic poisons such as arsena...

Abstract Background The urine immunochromatographic assay is a useful screening tool for patients suspected of acute drug intoxication in emergency conditions. Diphenhydramine shows symptoms similar to those tricyclic antidepressant (TCA) intoxication. Case presentation We examined case diphenhydramine showing cerebellar ataxia and prolonged false positive results TCA the urine. test showed per...

BACKGROUND Organophosphates are frequently used as insecticides in the household and in agricultural areas, thus posing a risk for accidental exposure. OBJECTIVES To describe the characteristics, clinical course and outcome of 97 patients admitted to emergency rooms with a diagnosis of acute OP poisoning. METHODS The clinical details of 97 patients were collected from 6 different hospitals ...

Chronic tissue ischemia due to defective vascular perfusion is a hallmark feature of peripheral artery disease for which minimal therapeutic options exist. We have reported that sodium nitrite therapy exerts cytoprotective effects against acute ischemia/reperfusion injury in both heart and liver, consistent with the model of bioactive NO formation from nitrite during ischemic stress. Here, we t...

The Neurospora crassa assimilatory nitrite reductase (EC 1.6.6.4) catalyzes the NADPH-dependent reduction of nitrite to ammonia, a 6-electron transfer reaction. Highly purified preparations of this enzyme exhibit absorption spectra which suggest the presence of a heme component (wavelength maxima for oxidized senzyme: 390 and 578 nm). There is a close correspondence between nitrite reductase ac...

A Desulfovibrio vulgaris Hildenborough mutant lacking the nrfA gene for the catalytic subunit of periplasmic cytochrome c nitrite reductase (NrfHA) was constructed. In mid-log phase, growth of the wild type in medium containing lactate and sulfate was inhibited by 10 mM nitrite, whereas 0.6 mM nitrite inhibited the nrfA mutant. Lower concentrations (0.04 mM) inhibited the growth of both mutant ...