OBJECTIVE The aim of this study was to evaluate the antioxidant and anti-inflammatory activities of Plai oil-encapsulated niosomes (Zingiber cassumunar Roxb.) on inflamed subcutaneous Wistar rat skin by therapeutic ultrasound. METHODS Pure oil from Plai rhizomes was extracted by steam distillation, and antioxidant activities were determined by 2,2-diphenyl-1-picrylhydrazyl radical scavenging ...

BACKGROUND Propolis is a multicomponent active, complex resinous substance collected by honeybees (Apis mellifera) from a variety of plant sources. This study was designed to improve the antimicrobial efficacy of propolis by engineering a niosomal-based system for topical application. METHODS Propolis was extracted in ethanol and screened for total polyphenol content. Propolis-loaded niosomes...

the aim of this investigation was to prepare, characterize and optimize the aceclofenac proniosomes using central composite design and carry out stability studies. three independent variables selected were molar ratio of drug to lipid (x1), surfactant loading (x2) and volume of hydration (x3). based on central composite design, 16 batches of proniosomes were prepared by slurry method and evalua...

objective(s): the purpose of the present study was to prepare and to evaluate a novel niosome as transdermal drug delivery system for propranolol hydrochloride and to compare the in vitro efficiency of niosome by either thin film hydration or hand shaking method. materials and methods: niosomes were prepared by thin film hydration (tfh) or hand shaking (hs) method. propranolol niosomes were pre...

The antileishmanial property of amarogentin, a secoiridoid glycoside isolated from the Indian medicinal plant Swertia chirata, was examined in a hamster model of experimental leishmaniasis. The therapeutic efficacy of amarogentin was evaluated in free and two different vesicular forms, liposomes and niosomes. The amarogentin in both liposomal and niosomal forms was found to be a more active lei...

Gene transfer to mesenchymal stem cells (MSCs) has arisen as a powerful approach increase the therapeutic potential of this effective cell population. Over recent years, niosomes have emerged self-assembled carriers with promising performance for gene delivery. The aim our work was develop niosomes-based DNA delivery platforms targeting MSCs. Niosomes based on 1,2-di-O-octadecenyl-3-trimethylam...

At present days drugs are formulated by using different novel drug delivery system (NDDS) which are used for targeting drugs to different organ systems and for controlled /sustained release of drug from the dosage forms. The NDDS can be used to overcome many disadvantages of conventional dosage forms like poor bioavailability, first pass effect, systemic toxicity, degradation of drug in stomach...

Abstract: Background/Aim: Inflammation typically occurs when infectious microorganisms enter the body, settle in specific tissues, and/or circulate blood. Asparagus racemosus extract contains various saponins and flavonoids plant-origin drugs have fewer side effects toxicity. The phytoconstituents less permeability through skin; to enhance their effectiveness it was loaded niosomes. Therefore, ...

Abstract Background Docetaxel (DTX) has been used to treat numerous types of cancers. Poor solubility, lower bioavailability, and serious side effects limit its use in cancer treatment. The objective the present research work was develop DTX-loaded niosomes overcome these issues investigate anticancer effect on breast cancer. Niosomes DTX were prepared evaluated estimate particle size, surface ...