Objective: Niosomal gel formulations containing phenytoin sodium have been prepared for enhancing skin wound healing. Methods: Solvent evaporation-film hydration methodology was adopted for noisome formation. Different compositions of phenytoin, surfactant and cholesterol were tested. The prepared niosomes were evaluated for size of vesicles, drug entrapment efficiency and release profiles. Res...

BACKGROUND/AIM The purpose of this study was to investigate and compare the pharmacokinetic behavior and tissue distribution of paclitaxel, delivered as commercial preparation Taxol or through Span 40 niosomes, after intravenous injection to rats. MATERIALS AND METHODS Paclitaxel-loaded Span 40 niosomes were prepared using the thin-film method. An HPLC method was developed and validated for p...

In this paper, we present a new modular lab on a chip design for multimodal neurotransmitter (NT) sensing and niosome generation based on a plug-and-play concept. This architecture is a first step toward an automated platform for an automated modulation of neurotransmitter concentration to understand and/or treat neurodegenerative diseases. A modular approach has been adopted in order to handle...

Purpose: To develop and evaluation ascorbyl palmitate niosomes in order to achieve a transdermal and/or systemic nanocarier of doxycycline. Methods: Vesicles were formed from ascorbyl palmitate in combination with cholesterol and a negatively charged lipid, dicetyl phosphate. Niosomes were prepared by film hydration method followed by sonication in which aqueous doxycycline solution (in phospha...

Over the years, researchers have attempted to improve potency of medicament utilization for treatment a variety diseases. Drug targeting is phenomenon in which drug distributed body such way that it interacts with target tissue at cellular or sub-cellular level achieve desired therapeutic response site while avoiding unwanted interactions other sites. This can be accomplished using modern deliv...

In recent years, nanocarriers have become potent drug delivery system candidates, especially in anti-HIV therapies. Meanwhile, using cell-penetrating peptides such as TAT for improvement of cellular transportation has been widely noticed. the current study, a novel PEGylated niosomal formulation (PEG-NI) loaded with an (Tenofovir) prepared by thin-film hydration method based on cholesterol and ...

Niosomes, non-ionic surfactant vesicles (NSVs), are the hydrated lipids composed mainly of different classes of non-ionic surfactants, introduced in the seventies as a cosmetic vehicle. Nowadays, niosomes are used as important new drug delivery systems by many research groups and also they are effective immunoadjuvants which some commercial forms are available in the market. These vesicles rece...

Our previous study demonstrated the potent in vitro collagen biosynthesis stimulating and antioxidant activities of Volvariella volvacea extract. This study was performed the loading of V. volvacea extract (VV) in niosomes (NV). The physicochemical characterization of the VV loaded niosomes and gel containing niosome of the extract (GNV) was studied. Rat skin transdermal absorption by Franz dif...

OBJECTIVE The aim of this study was to evaluate the antioxidant and anti-inflammatory activities of Plai oil-encapsulated niosomes (Zingiber cassumunar Roxb.) on inflamed subcutaneous Wistar rat skin by therapeutic ultrasound. METHODS Pure oil from Plai rhizomes was extracted by steam distillation, and antioxidant activities were determined by 2,2-diphenyl-1-picrylhydrazyl radical scavenging ...