To determine if changes in pulmonary capillary wedge pressure could be determined from the pulmonary blood volume (PBV) ratio response on exercise-gated blood pool images, 42 patients had simultaneous exercise-gated blood pool imaging and hemodynamic monitoring during cardiac catheterization. Nine patients were normal and 33 patients had cardiac disease. Changes in the PBV ratio were determined...

The exercise tolerance of the survivors of a consecutive group of 100 patients in a renal dialysis and transplant programme was compared with the prevalence of cardiac abnormalities detected by exercise testing, echocardiography, and radionuclide angiography. Fifty four patients attended for investigation 27 (SD 7) months after starting renal replacement therapy. Forty three of them (80%) were ...

Nine patients with chronic heart failure (New York Heart Assaciation Function Class 3) were studied using ctandard methods. Oxygen saturation was measured in the ahpatic w i n (splanchnic circulation), femoral vein (working muscle) and in mixed venous blood. Measurements were made after 2 minutes at each exercise level and after exercise at 2,5,10 and 15 minutes. Resultrare given as mean valuer...

A 12 lead electrocardiogram was recorded during treadmill exercise in 57 patients with variant angina in whom coronary angiography was performed. Thirty six patients performed exercise tests with and without calcium antagonists, and 21 performed them only with calcium antagonists. In 55 patients calcium antagonists had prevented spontaneous attacks of variant angina for more than two days befor...

'Cardiosomes' (exosomes from cardiomyocytes) have recently emerged as nanovesicles (30-100 nm) released in the cardiosphere by myocytes and cardiac progenitor cells, though their role in diabetes remains elusive. Diabetic cardiovascular complications are unequivocally benefitted from exercise; however, the molecular mechanisms need exploration. This novel study is based on our observation that ...

This important observation prompted us to report here the results of a prospective study that we conducted during the 1990s, which has only been published in abstract form [2]. Nine male COPD patients with mild hypoxaemia at rest (six current and three ex-smokers) were included in the study (age: 66.9¡5.8 yrs, forced expiratory volume in one second/ forced vital capacity: 43.2¡15.5% predicted, ...

OBJECTIVE Diabetic individuals have impaired endothelium-dependent forearm vasodilatory responses to ischemia, acetylcholine, and other endothelium-dependent agonists. The functional significance of impaired endothelium-dependent dilation in diabetic individuals is uncertain but is most likely to be manifest during leg muscle exercise and may have relevance to peripheral vascular disease and le...

Nitric oxide (NO) synthase inhibition reduces leg glucose uptake during cycling without reducing leg blood flow (LBF) in young, healthy individuals. This study sought to determine the role of NO in glucose uptake during exercise in individuals with type 2 diabetes. Nine men with type 2 diabetes and nine control subjects matched for age, sex, peak pulmonary oxygen uptake (VO(2) peak), and weight...