Nifedipine produced significant hyperglycemia but rise' in blood sugar was not dose dependent (Table I). Nifedipine also increased blood sugar in rats rendered hyperglycemic by alloxon (193 ± lO.7 and 224 ± 9.3 mg%, n = 6, p < 0.05). Nifedipine Sr. No. of Dose of No. animals nefedipine mglkg (150 mgfkg) was injected sc 2 days prior to sacrificing animals. After 3 weeks of nifedipine treatment b...

Mice were rendered tolerant and dependent to morphine by subcutaneous injection of morphine over a period of 5 days. The effects of acute and chronic administration of dihydropyridine calcium channel antagonist nifedipine on the development of tolerance and naloxone-precipitated morphine withdrawal signs were investigated. A single injection of nifedipine proved to be effective in inhibiti...

We performed a prospective, randomized, double-blind, crossover study to compare the efficacy and safety of vasodilation with the calcium entry blocker nifedipine with that of isosorbide dinitrate (ISDN) and their combination as treatment for heart failure. Twenty-eight patients with New York Heart Association Functional class II or III chronic heart failure due to left ventricular systolic dys...

nifedipine (nif), a 1,4-dihydropyridine calcium channel antagonist, undergoes photo-degradation to dehydro-nifedipine (dnif) upon exposure to ultraviolet (uv) light and to the nitroso analogue of dehydro-nifedipine (ndnif) when exposed to sunlight or some kinds of artificial lights. nif photo-degradation products do not contribute to clinical activity, thus prevention of photo-degradation of ni...

Nifedipine is frequently used for patients who require an immediate reduction of blood pressure elevated temporarily by various administration techniques including sublingual route without administrating intravenous infusion of vasodilator. A cross-over clinical study was conducted to investigate the optimal administration method of nifedipine for rapid management of hypertension. Four method o...

Nine patients with uncomplicated essential hypertension received, according to a randomized sequence, captopril (25 mg three times daily), nifedipine (10 mg three times daily), and both drugs for 1 week, with each treatment period separated by a 1-week interval during which a placebo was given. Captopril significantly reduced blood pressure and plasma aldosterone, increased plasma renin activit...

Nifedipine, a calcium channel blocker, has been reported to exert pleiotropic effects on atherosclerosis, mainly through its antioxidative properties. However, the effect of the calcium channel blocker on cognitive impairment associated with type 2 diabetes mellitus is not well known. Here, we examined the possibility that a calcium channel blocker could improve cognitive function in a type 2 d...

The pharmacopoeial quality of non-expired and expired nifedipine tablets of the same batches purchased from the Estonian and Russian Federation medicinal product markets was evaluated. The IR spectroscopy, HPLC analysis for quantitative content and purity of the active pharmaceutical ingredient (API), and dissolution test techniques were applied. In the experiments with non-expired nifedipine t...