OBJECTIVE To determine the efficacy and safety of nifedipine as a tocolytic agent in women with preterm labor. STUDY DESIGN A systematic review and metaanalysis of randomized controlled trials. RESULTS Twenty-six trials (2179 women) were included. Nifedipine was associated with a significant reduction in the risk of delivery within 7 days of initiation of treatment and before 34 weeks' gest...

The relative efficacy of nifedipine and slow-release nifedipine (Adalat Retard) in the treatment of stable exertional angina pectoris was evaluated in a double blind randomised crossover study in eight patients on no concomitant antianginal treatment and in 10 patients who were additionally on atenolol. Patients were assessed by angina diaries and exercise testing. Slow-release nifedipine was a...

A 84-year-old man was given nifedipine for control of angina pectoris. Acute psychosis with paranoid ideation developed soon after he began receiving the medication. All symptoms resolved with discontinuation of nifedipine. This is the second reported case of nifedipine-associated acute psychosis. Alternations in calcium-mediated neurotransmitter release, particularly dopamine, may be responsib...

BACKGROUND The efficacy and safety of sustained-release nifedipine for the treatment of primary Raynaud phenomenon (RP) has not previously been demonstrated by a randomized, controlled trial. Temperature biofeedback has been studied in patients with primary RP but not in a large multicenter controlled trial or compared with nifedipine therapy. OBJECTIVE To evaluate and compare the effectivene...

statement of problem: in recent years, numerous reports have been presented in the literature, about gingival overgrowth induced by nifedipine- a calcium antagonist- prescribed for hypertension and certain types of angina. purpose: the purpose of the present study was to investigate the prevalence rate of nifedipine induced gingival hyperplasia in patients and its probable relationship with age...

A 65-year-old Chinese man was admitted for evaluation of chronic anaemia. He had a history hypertension and kidney disease, his regular medications were nifedipine losartan. retired cleaner who lived with friends no contact family. referred to the Dermatology clinic thick, brown

OBJECTIVE To review the available data about the use of nifedipine to treat hypertension in pregnancy. DATA SOURCES All English language cases and studies published after 1984 and indexed in MEDLINE, Excerpta Medica, and BIOSIS PREVIEWS under the headings nifedipine, hypertension in pregnancy, uteroplacental blood flow, maternal/fetal hemodynamics, preeclampsia, and pregnancy outcome. MAIN ...

Nifedipine, a hypertensive calcium channel blocker, is commonly administered to subjects with coronary heart disease who often exhibit hyperlipidemia. In general, the pharmacokinetic consequences of hyperlipidemia include increased total drug concentrations and decreased unbound fraction in plasma. However, the pharmacodynamic consequences of hyperlipidemia are conflicting; unaltered, increased...

Objective. Evaluating changes in the power spectral density (PSD) peak frequency of the electrohysterogram (EHG) caused by nifedipine in women with preterm contractions. Methods. Calculation of the PSD peak frequency in EHG contraction bursts at different times of nifedipine treatment in women in gestational age 24 to 32 weeks with contractions. Results. A significant (P < .05) decrease of PSD ...

OBJECTIVE Nifedipine, an L-type calcium channel blocker, protects against the progression of atherosclerosis. We investigated the molecular basis of the antiatherosclerotic effect of nifedipine in macrophages and apolipoprotein E-deficient mice. METHODS AND RESULTS In macrophages, nifedipine increased peroxisome proliferator-activated receptor-gamma (PPARgamma) activity without increasing PPA...