Psoriasis is an inflammatory skin disease in which activated immune cells and the proinflammatory cytokine TNF are well-known mediators of pathogenesis. The transcription factor NF-kB is a key regulator of TNF production and TNF-induced proinflammatory gene expression, and both the psoriatic transcriptome and genetic susceptibility further implicate NF-kB in pso-riasis etiopathology. However, t...

True, Andrea L., Arshad Rahman, and Asrar B. Malik. Activation of NF-kB induced by H2O2 and TNF-a and its effects on ICAM-1 expression in endothelial cells. Am J Physiol Lung Cell Mol Physiol 279: L302–L311, 2000.— Reactive oxygen species have been proposed to signal the activation of the transcription factor nuclear factor (NF)-kB in response to tumor necrosis factor (TNF)-a challenge. In the ...

Stimulation of endothelial cells by cytokines and bacterial lipopolysaccharide leads to activation f the transcription factor NF-KB. NF-KB in turn regulates the expression of several genes involved in the inflammatory reaction, including cell adhesion molecules, interleukins, and transcription factors. One of these induced genes encodes an inhibitor of NF-KB, ECI-~/IKB~, that contains in its 5‘...

Activation of inflammatory gene expression by the transcription factor NF-kB is a central pathway in many inflammatory disorders, including colitis. Increased NF-kB activity has been linked with development of colitis in humans and animal models, thus it was unexpected when NF-kB-deficient mice developed spontaneous typhlocolitis. To further characterize this finding, we induced typhlocolitis i...

Bcr–Abl is a chimeric oncoprotein that is strongly implicated in acute lymphoblastic (ALL) and chronic myelogenous leukemias (CML). This deregulated tyrosine kinase selectively causes hematopoietic disorders resembling human leukemias in animal models and transforms fibroblasts and hematopoietic cells in culture. Bcr–Abl also protects cells from death induced on cytokine deprivation or exposure...

Background and Purpose—An acute inflammatory response exacerbates tissue injury during acute ischemic stroke. The transcription factor nuclear factor (NF)-kB plays a key role in endothelial cell activation and the inflammatory response. Targeted genetic disruption of NF-kB activation in cerebral endothelial cells may be protective in stroke. We determined whether a NF-kB transcription factor de...

Takahashi, Satoru, Takuya Fujita, and Akira Yamamoto. Role of nuclear factor-kB in gastric ulcer healing in rats. Am J Physiol Gastrointest Liver Physiol 280: G1296–G1304, 2001.—We investigated the role of nuclear factor-kB (NF-kB) in gastric ulcer healing in rats. NF-kB was activated in ulcerated tissue but not in normal mucosa, and the level of the activation was decreased with ulcer healing....

Jobin, Christian, and R. Balfour Sartor. The IkB/NF-kB system: a key determinant of mucosal inflammation and protection. Am. J. Physiol. Cell Physiol. 278: C451–C462, 2000.—The ubiquitous transcription factor NF-kB is a central regulator of the transcriptional activation of a number of genes involved in cell adhesion, immune and proinflammatory responses, apoptosis, differentiation, and growth....

Several reports indicated that nuclear factor kB (NF-kB) activation by cytokines, cytotoxic drugs, or ionizing radiation protects cells against apoptosis. Therefore, we investigated the consequence of NF-kB inhibition on the efficiency of antineoplastic agents. HPB, HCT116, MCF7, and OVCAR-3 cells stably expressing a dominant negative IkBa inhibitor showed a decreased NF-kB activation following...