The non-canonical NF-κB pathway is crucial for the immune system. A critical event in activation of the non-canonical pathway is the attenuation of NF-κB-inducing kinase (NIK) degradation, which is promoted by continuous polyubiquitination of NIK catalyzed by the NIK ubiquitin-ligase complex composed of cellular inhibitor of apoptosis protein 1 and 2 (cIAP1/2), TNF receptor-associated factor 2 ...

BACKGROUND Water extract from the root of Allium hookeri (AH) shows anti-inflammatory, antioxidant, and free radical scavenging effects. In this study, the ameliorating effects of AH on oxidative stress-induced inflammatory response and β-cell damage in the pancreas of streptozotocin (STZ)-induced type 1 diabetic rats were investigated. METHODS AH (100 mg/kg body weight/day) was orally admini...

BACKGROUND Evidence suggests that activation of κ-opioid receptor (KOR) by U50,488H exhibits potential cardiovascular protective properties. However, the effects of U50,488H on vascular dysfunction in diabetes mellitus (DM) are still not clear. The present study was designed to investigate the effects of U50,488H on vascular dysfunction in diabetic rats and explore the underlying mechanisms inv...

Abstract Hepatocellular carcinoma (HCC) has a desmoplastic and hypoxic tumor microenvironment (TME), resulting in poor prognosis treatment resistance. This study aimed to construct novel prognostic classifier investigate the degree of hypoxia immune profiles HCC. Patients with HCC from public databases were classified into three HIF-1α clusters according 16 reported HIF-1α-related genes. Then, ...

Abstract The outbreak of novel coronavirus pneumonia (COVID-19), defined as a worldwide pandemic, has been public health emergency international concern. Pudilanxiaoyan oral liquid (PDL), an effective drug Traditional Chinese Medicine (TCM), is considered to be and alternative means for clinical prevention COVID-19. purpose this study was identify potential active constituents PDL, explore its ...