As the first responders, neutrophils lead innate immune response to infectious pathogens and inflammation inducing agents. The well-established pathogen neutralizing strategies employed by are phagocytosis, action of microbicide granules, production ROS, secretion neutrophil extracellular traps (NETs). Only recently, ability sense respond pathogen-associated molecular patterns is being apprecia...

Neutrophil extracellular traps (NETs) were initially described as an antimicrobial mechanism of neutrophils. Over the last decade, several lines of evidence support the involvement of NETs in a plethora of pathological conditions. Clinical and experimental data indicate that NET release constitutes a shared mechanism, which is involved in a different degree in various manifestations of non-infe...

The accumulation of amyloid fibrils is a feature of amyloid diseases, where cell toxicity is due to soluble oligomeric species that precede fibril formation or are formed by fibril fragmentation, but the mechanism(s) of fragmentation is still unclear. Neutrophil-derived elastase and histones were found in amyloid deposits from patients with different systemic amyloidoses. Neutrophil extracellul...

Neutrophils release neutrophil extracellular traps (NETs) which ensnare pathogens and have pathogenic functions in diverse diseases. We examined the NETosis pathways induced by five stimuli; PMA, the calcium ionophore A23187, nigericin, Candida albicans and Group B Streptococcus. We studied NET production in neutrophils from healthy donors with inhibitors of molecules crucial to PMA-induced NET...

Neutrophils extrude neutrophil extracellular traps (NETs) consisting of a network of chromatin decorated with antimicrobial proteins to enable non-phagocytic killing of microorganisms. Here, utilizing a model of ex vivo activated human neutrophils, we present evidence of entrapment and degradation of carboxylated single-walled carbon nanotubes (SWCNTs) in NETs. The degradation of SWCNTs was cat...

Abstract Backgrounds and aim Neutrophil extracellular traps (NETs) have been shown to play an important role in inflammatory thrombotic processes. Investigating the presence of NETs liver cirrhosis detect any contribution occurrence complications may help predict or prevent those complications. Methods Among 78 cirrhotic patients, serum level was measured using ELISA compared different etiologi...

Neutrophil extracellular traps (NETs) have been described as a fundamental innate immune defence mechanism. They consist of a nuclear DNA backbone associated with different antimicrobial peptides (AMPs) which are able to engulf and kill pathogens. The AMP LL-37, a member of the cathelicidin family, is highly present in NETs. However, the function of LL-37 within NETs is still unknown because it...

Infections are a major contributor to lupus disease. Uropathogenic E. coli (UPEC) is responsible for the majority of urinary tract infections in both healthy individuals and patients. We have previously demonstrated that bacterial amyloid curli complexes curli/DNA, produced by E.coli, can accelerate disease mouse models lupus. Moreover we extended these findings human demonstrate curl...

Introduction Juvenile-onset Systemic Lupus Erythematosus (JSLE) is a multisystem autoimmune disorder characterized by the overproduction of autoantibodies against nuclear selfantigens. Activated neutrophils may undergo cell death by NETosis, forming mesh-like structures termed Neutrophil extracellular traps (NETs). Comprising of DNA, histones and antimicrobial proteins, increasing evidence impl...

Introduction A novel antimicrobial mechanism of neutrophils involves the release of neutrophil extracellular traps (NETs) into the local environment to bind pathogens. NETs are composed of chromatin, and it has been proposed that a source of autoantigens in Systemic Lupus Erythematosus (SLE) could be increased NETs production. Interferon (IFN)-a is known to be a key player in the pathogenesis o...