Neutrophil recruitment into inflamed tissue in response to injury or infection is tightly regulated. Reduced neutrophil recruitment can result in a reduced ability to fight invading microorganisms. During inflammation, neutrophils roll along the endothelial wall of postcapillary venules and integrate inflammatory signals. Neutrophil activation by selectins and chemokines regulates integrin adhe...

Neutrophils provide a critical line of defense in immune responses to various pathogens, inflicting self-damage upon transition hyperactivated, procoagulant state. Recent work has highlighted proinflammatory neutrophil phenotypes contributing lung injury and acute respiratory distress syndrome (ARDS) patients with coronavirus disease 2019 (COVID-19). Here, we use state-of-the art mass spectrome...

Neutrophil and platelet are essential arms of the innate immune response. In sepsis, platelet abnormal activation as well as neutrophil paralysis are well recognized. For platelet, it is characterized by the contribution to disseminated intravascular coagulation (DIC) and the enhanced inflammation response. In terms of neutrophil, its dysfunction is manifested by the impaired recruitment and mi...