One hundred myelographies with iopamidol and 100 with metrizamide were performed in order to compare the side effects of the two contrast media after injection into the spinal subarachnoid space. All patients were observed for a follow-up period of at least 4 days. The most frequently observed side effect, headache, was more common, of longer duration, and more severe with the use of metrizamid...

CYCLOSPORINE (CyA) has been shown to be effective in a variety of human autoimmune diseases. including psoriasis, nephrotic syndrome, type I diabetes, and sight-threatening uveitis. 1 Its potential side effects include nephrotoxicity, diabetogenicity, and neurotoxicity. Several studies (see elsewhere in this symposium) have shown that FK 506 prevents or suppresses autoimmune disorders in experi...

Several lines of evidence suggest that some neurotoxicity in AD is due to proteolytic fragments of APP. In this study, we compared the potency of neurotoxicity induced by CT with that of A-beta neurotoxicity and our results showed that various CT peptide fragments (CTFs; CTF99, AICD, CTF31) caused neurotoxicity in cultured cells and primary cortical neurons, induced strong non-selective inward ...

Alzheimer's disease is accompanied by progressive, time-dependent changes of three moieties of amyloid beta. In vitro models therefore should provide same conditions for more physiologic studies. Here we observed changes in the number of fibrils over time and studied the correlation between amyloid beta moieties and neurotoxicity. Although the number of fibrils increased dramatically, the chang...

They are used as pesticides but can also be used as 'nerve gas'. This is prohibited under the Geneva Convention but could be used by terrorists or rogue regimes. There is some suggestion that the use of OP pesticides may have caused some neurotoxicity and be responsible for 'Gulf War syndrome'. Certainly, insecticides were freely used, as were many other chemicals. The syndrome is inconsistent ...

OBJECTIVE Conus medullaris syndrome (CMS) is a clinical neurologic syndrome caused by a conus medullaris lesion. CMS is a heterogeneous entity with various etiologies such as trauma or a space-occupying lesion. Multiple cases of CMS following spinal anesthesia have been reported, but CMS after radioisotope (RI) cisternography has not yet been reported. METHODS We present four patients who dev...

Recently, we reported that mutations in the neuropathy target esterase (NTE) gene cause autosomal recessive motor neuron disease (NTE-MND). We describe clinical, neurophysiologic, and neuroimaging features of affected subjects in the index families. NTE-MND subjects exhibited progressive lower extremity spastic weakness that began in childhood and was later associated with atrophy of distal leg...

the present study was focused upon the assessment of acetyl-cholinesterase (ache) activity in the digestive gland (main metabolic center) and foot (highly innervated organ) of the green garden snail, cantareus apertus (born, 1778), exposed to different nominal dietary concentrations of pb (25 and 2500 mg pb/kg), cd (10 and 100 mg cd/kg) and their combination (25 mg pb + 10 mg cd/kg and 2500 mg ...