Systemic lupus erythematosus (SLE) is an auto­ immune disorder mediated by the immune­ complex and characterised by its protean clinical mani festation and multisystemic involvement (Mak 2007a). Neuropsychiatric manifestation of SLE (NPSLE) is one of the major and most damag ing presentations. It comprises a wide range of neurological syndromes affecting the central, peripheral and autonomic ne...

UNLABELLED The management of neuropsychiatric systemic lupus erythematosus (NPSLE) still remains empirical and based on clinical experience due to the lack of randomized controlled trials. OBJECTIVE To report the experience accumulated in a single tertiary referral centre about treatment of severe cases of NPSLE patients and to discuss therapeutic strategies on the background of EULAR recomme...

Background: Brucellosis is a zoonotic infection which is endemic in many countries. It is a multisystem disease which may present with a broad spectrum of clinical manifestations and complications. Neurobrucellosis is an uncommon complication of brucellosis. Case presentation: A 25-year-old woman with a history of lupus for 5 months referred to the emergency ward of Shahid Beheshti Hosp...

this case report demonstrates fatal gastrointestinal vasculitis as a rare presentation of systemic lupus erythematosus. a 34-year-old woman presented with abdominal pain and diarrhea. anti nuclear antibody was positive and high titre of anti-ds dna antibody was also reported. treatment with corticosteroid and supportive cares were started; however, her condition worsened. eventually, she was co...

hemophagocytic syndrome (hps) is an uncommon manifestation in systemic lupus erythematosus (sle). clinical features of hps include fever, pancytopenia, abnormal liver enzyme, hepatosplenomegaly, lymphadenopathy, and coagulation disorder. hps comprises primary and reactive forms. herein, we describe a case of untreated sle with hps as one of the first manifestations of systemic lupus.

gastrointestinal (gi) and hepatic manifestations are not uncommon in patients with systemic lupus erythematosus (sle). they include nonspecific symptoms as well as serious, life-threatening complications necessitating urgent, aggressive therapy. in addition to direct involvement of the gi system by the disease, many drug-induced side effects and opportunistic infections have gi and hepatic mani...

Neuropsychiatric manifestations are common presenting features in systemic lupus erythematosus. Many a times they appear much earlier than other signs and symptoms of systemic involvement. This case report highlights the difficulty in diagnosis and importance of screening patients with specific test when the presentations are not clear.

conclusions silent ventricular systolic dysfunction was more common in the patients with sle than in the control group. newer echocardiographic techniques such as two-dimensional ste provide an earlier chance for the detection of subclinical lv systolic dysfunction. our findings were independent of the traditional risk factors. results the mean duration of sle was 5.5 ± 3.4 years in our patient...