نتایج جستجو برای: neuromelanin nm
تعداد نتایج: 126090 فیلتر نتایج به سال:
Substantial evidence indicates that neuroinflammation caused by microglial activation in substantia nigra is critical in the pathogenesis of dopaminergic neurodegeneration in Parkinson's disease (PD). Increasing data demonstrates that environmental factors such as rotenone, paraquat play pivotal roles in dopaminergic neuron death. Here, potential role and mechanism of neuromelanin (NM), a major...
Tyrosinase, a widely spread enzyme in micro-organisms, animals, and plants, participates in two rate-limiting steps in melanin formation pathway which is responsible for skin protection against UV lights' harm whose functional deficiency result in serious dermatological diseases. This enzyme seems to be responsible for neuromelanin formation in human brain as well. In plants, the enzyme leads t...
The locus coeruleus (LC) is the principal origin of noradrenaline in the brain. LC integrity varies considerably across healthy older individuals, and is suggested to contribute to altered cognitive functions in aging. Here we test this hypothesis using an incidental memory task that is known to be susceptible to noradrenergic modulation. We used MRI neuromelanin (NM) imaging to assess LC struc...
34 Recent models posit that bursts of locus coeruleus (LC) activity amplify neural gain, such that 35 limited attention and encoding resources focus even more on prioritized mental representations 36 under arousal. Here, we tested this hypothesis in human males and females using functional 37 magnetic resonance imaging (fMRI), neuromelanin MRI, and pupil dilation, a biomarker of 38 arousal and ...
[F-18]-AV-1451 is a novel positron emission tomography (PET) tracer with high affinity to neurofibrillary tau pathology in Alzheimer's disease (AD). PET studies have shown increased tracer retention in patients clinically diagnosed with dementia of AD type and mild cognitive impairment in regions that are known to contain tau lesions. In vivo uptake has also consistently been observed in midbra...
As the most efficacious drug for treating Parkinson’s disease, levodopa (L-DOPA), is oft viewed as a generator of reactive oxygen species (ROS), there is a question as to whether L-DOPA might accelerate progression of Parkinson’s disease. In this context we first review the potential of both L-DOPA and dopamine (DA) to generate ROS (including catecholquinones) in the presence of iron and melani...
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