Objective Neurometabolic disorders are an important group of diseases that mostly are presented in newborns and infants. Neurological manifestations are the prominent signs and symptoms in this group of diseases. Seizures are a common sign and are often refractory to antiepileptic drugs in untreated neurometabolic patients. The onset of symptoms for neurometabolic disorders appears after an int...

Introduction. The hyperdense internal carotid artery sign (HICAS) has been suggested as a common marker of terminal internal carotid artery (ICA) thrombus associated with poor outcomes following thrombolysis. We aimed to investigate the prevalence and prognostic significance of the HICAS in an unselected cohort of patients receiving intravenous thrombolysis. Methods. Prethrombolysis NCCTs of 12...

BACKGROUND Behçet's Disease (BD) is characterized by a relapsing-remitting course, with symptoms of varying severity across almost all organ systems. There is a diverse array of therapeutic options with no universally accepted treatment regime, and it is thus important that clinical practice is evidence-based. We reviewed all currently available literature describing management of BD, and inves...

Dysfunction of the sense smell and taste may have severeimpact on quality life overall health. Detection ofbad in local environment is a warning sign for aperson good pleasurable life. Similarlysense also very important pleasure toavoid intake hazardous meal or drink. Unfortunately,knowledge about dysfunction verylimited little work has been conducted this field.There long list disorders diseas...

Abscesses secondary to pituitary adenoma are rare. The common clinical manifestations often encountered headaches, meningismus, and visual disturbances. Hemiplegia as its revealing sign is uncommon. To the best of our knowledge, this second reported case a abscess with focal neurological deficit half-sided body. We report 52-year-old woman successfully treated by stereotactic evacuation inside ...

np-c is a severe, progressive and irreversible neurovisceral disease, which is invariably fatal. np-c is a rare disease, with an estimated minimal incidence of 1/120,000 live births . np-c is caused by mutations in npc1 (~95% of patients) or npc2 genes .defective npc1 and npc2 proteins result in a disruption of lipid metabolism . one of special features of this disorder is heterogeneous manifes...

it has been estimated that more than 1.7 million individuals suffer a traumatic brain injury (tbi) each year. tbi causes secondary biochemical and metabolic changes which contribute to subsequent tissue damage and associated neuronal cell death. two early and delayed events occur after tbi, which results in neurological deficits. primary injury events include the mechanical damage that occur at...

BACKGROUND Soft neurological signs are minor, non localizing, objective abnormalities, thought to reflect damage in cortical and sub-cortical connections or connections within different cortical regions. Regional structural grey matter anomalies have already been observed and correlated with the presence of cognitive deficits and presence of soft neurological signs in schizophrenic patients. ...

superficial siderosis (ss) is a rare disease which affects people in all ages and both sexes, but three times more in men. pathological etiology is deposition of hemosiderin (a product of the breakdown of blood) in leptomeninges, subpial layer, ependymal surface and other parts of central nervous system (cns) and typically leads to neurological dysfunction and progressive irreversible signs and...