Introduction: Cytokines production as one of the inflammatory pathways in CNS is responsible for most brain damages following ischemia. On the other hand, during inflammation and brain ischemia, most of the renin- angiotensin components (RAS) increase locally. While it is established that blockade of RAS especially AT1 receptors has a protective effect on ischemia, the interaction of cytokines ...

OBJECTIVE This study was carried out to evaluate whether the type of pump used for cardiopulmonary bypass (CPB; roller vs. centrifugal) can affect mortality or the neurological outcomes of adult cardiac surgery patients. METHODS Between 1994 and June 1999, 4000 consecutive patients underwent coronary and/or valve surgery at our hospital; of these, 2213 (55.3%) underwent surgery with centrifug...

BACKGROUND AND PURPOSE A single-center prospective randomized controlled trial has been conducted to determine if lumbar drainage of cerebrospinal fluid after aneurysmal subarachnoid hemorrhage reduces the prevalence of delayed ischemic neurological deficit and improves clinical outcome. METHODS Patients with World Federation of Neurological Surgeons Grade 1 to 3 aneurysmal subarachnoid hemor...

introduction sub axial cervical spine dislocations are common and managing these cases by closed reduction is successful in the majority of cases. however, treatment of old and neglected cases is difficult and the results may vary in terms of neurological and functional outcomes. case presentation we present two cases of traumatic bilateral cervical facet dislocation with no neurological defici...

Background: Stroke is the third leading cause of invalidism and death in industrialized countries. There are conflicting reports about the effects of Angiotensin II on ischemia-reperfusion brain injuries and most data have come from chronic hypertensive rats. In this study, hypotensive and non-hypotensive doses of candesartan were used to investigate the effects of angiotensin II AT1 receptor b...

Background and Purpose—A single-center prospective randomized controlled trial has been conducted to determine if lumbar drainage of cerebrospinal fluid after aneurysmal subarachnoid hemorrhage reduces the prevalence of delayed ischemic neurological deficit and improves clinical outcome. Methods—Patients with World Federation of Neurological Surgeons Grade 1 to 3 aneurysmal subarachnoid hemorrh...

BACKGROUND AND PURPOSE Current guidelines suggest that cardiac arrest (CA) survivors should be ventilated with 100% O(2) after resuscitation. Breathing 100% O(2) may worsen neurological outcome after experimental CA. This study tested the hypothesis that graded reoxygenation, with oximetry guidance, can safely reduce FiO(2) after resuscitation, avoiding hypoxia while promoting neurological reco...

BACKGROUND AND PURPOSE Mechanisms of ischemia/reperfusion brain injury include altered patterns of energy metabolism that may be amenable to pharmacological manipulation. The purpose of this study was to test the effectiveness of postischemic acetyl-L-carnitine administration on potentiation of metabolic recovery and prevention of neurological morbidity in a clinically relevant model of complet...

background: stroke is the third leading cause of invalidism and death in industrialized countries. there are conflicting reports about the effects of angiotensin ii on ischemia-reperfusion brain injuries and most data have come from chronic hypertensive rats. in this study, hypotensive and non-hypotensive doses of candesartan were used to investigate the effects of angiotensin ii at1 receptor b...