Alzheimer’s disease (AD) is an irreversible, neurodegenerative disorder characterised by the progressive loss of memory and thinking skills. It was first presented at a meeting in 1906 by Dr. Alois Alzheimer, a German psychiatrist, who discovered ‘‘neurofibrillary tangles’’ in the brain tissue of a woman who died with dementia at the age of 55. It was not until the tangle could be isolated and ...

A clinicopathological report is presented of a British male, aged 59 years, who died after an illness of 10 years, manifested by progressive respiratory failure, ptosis, and dysphagia. At no time was there evidence of ophthalmoplegia, Parkinsonism or dementia. At necropsy the main finding was of neurofibrillary tangles in the neurons of the pontine and medullary reticular formation, with partic...

Dementia constitutes one of the greatest médical and social problems facing the aging populations of developed countries. Alzheimer's disease is the main cause of dementia in the eiderly, and the cognitive décline that characterizes this disorder clinically is accompanied by the development of hallmark neuropathological changes, including loss of neurons and synapses and the development of seni...

Alzheimer’s disease (AD) is known for some well-characterized pathological changes including the extracellular accumulation of amyloid plaques, intra-neuronal presence of neurofibrillary tangles, glial hypertrophy and neuronal death [1-3]. Paradoxically, myelin pathology in human AD has not been widely studied, even though it has been more than a century since Alois Alzheimer described myelin d...

1 Alzheimer’s disease (AD) is the most common cause of dementia in the elderly. Typically, the disease progresses in a prolonged, inexorable manner [1]. Patients initially show symptoms of mild cognitive impairment, which may include some memory loss. As the disease progresses, more severe memory loss occurs (e.g., retrograde amnesia) leading to confusion and lack of orientation. The patient is...