The fetal skeleton arises from neural crest and from mesoderm. Here, we provide evidence that each lineage contributes a unique stem cell population to the regeneration of injured adult bones. Using Wnt1Cre::Z/EG mice we found that the neural crest-derived mandible heals with neural crest-derived skeletal stem cells, whereas the mesoderm-derived tibia heals with mesoderm-derived stem cells. We ...

Wnt signaling is implicated in the control of cell growth and differentiation during CNS development from studies of mouse and chick models, but its action at the cellular level has been poorly understand. In this study, we examine the in vitro function of Wnt signaling in embryonic neural stem cells, dissociated from neurospheres derived from E11.5 mouse telencephalon. Conditioned media contai...

Hypoxic ischemic encephalopathy is a serious condition due to inadequate oxygen supply to the brain. Regeneration of neural cells is a critical process for repairing the damaged brain. Nogo has been identified as an inhibitor of neurite outgrowth that is specific to the brain. In the present study, the Nogo-A receptor (NgR) antagonist NEP1-40 was used to study the effects of inhibition of NgR o...

s of the 14th Annual Meeting of the Japanese Society for Neural Growth, Regeneration and Transplantation 1. Oxidized Galectin-1 Regulates Initial Repair in Peripheral Nerves after Axotomy (II) – Initial Regulation of Neural Regeneration in Sciatic Nerves After Axotomy Hidenori Horie1, Yoshimasa Inagaki2, Yoshiaki Sohma2, Risa Nozawa2, Mitsuhiro Hasegawa3, Naoki Muramatsu3, Hitoshi Kawano4, Masa...

The regeneration of skeletal muscles is a suitable model to study the development and differentiation of contractile tissues. Neural effects are one of the key factors in the regulation of this process. In the present work, effects of different reinnervation protocols (suture or grafting) were studied upon the regenerative capacity of rat soleus muscles treated with the venom of the Australian ...

Large numbers of people suffer from nervous system injuries and neurodegenerative diseases each year, with little success in regaining lost neural functions. Attempts to successfully regenerate nervous tissue in the mammalian Central Nervous System have meet with limited success. Simpler models have thus been useful in determining conserved mechanisms in the enhancement of neural regeneration. ...

The microenvironment of neuron cells plays a crucial role in regulating neural development and regeneration. Hyaluronic acid (HA) biomaterial has been applied in a wide range of medical and biological fields and plays important roles in neural regeneration. PC12 cells have been reported to be capable of endogenous NGF synthesis and secretion. The purpose of this research was to assess the effec...

Submit Manuscript | http://medcraveonline.com Abbreviations: CAPS-2: Calcium dependent Activator Protein for Secretion 2; BDNF: Brain Derived Neurotrophic Factor; CXCR4: Chemokine Receptor with CXC Motif 4; GABA: Gamma Amino-Butyric Acid; GABA A receptor: Gamma Amino-Butyric Acid Receptor A; GAERS: Genetic Absence Epilepsy Rats from Strasbourg; LGS: Lennox-Gastaut Syndrome; MAP-2: Microtubule A...

Spinal cord injury (SCI) is one of the devastating conditions leading to functional and neurological deficits following road traffic accidents. To date, there is no definite treatment for repairing damaged spinal cord tissue. In this regard, cell therapy opens a new window in front of scientists by using different cells such as mesenchymal stem cells, olfactory ensheathing cells, Schwann cells,...

Tissue regeneration depends on proliferative cells and on cues that regulate cell division, differentiation, patterning and the restriction of these processes once regeneration is complete. In planarians, flatworms with high regenerative potential, muscle cells express some of these instructive cues. Here, we show that members of the integrin family of adhesion molecules are required for the in...