Background Brain hubs are highly connected regions important for integrating cognitive processing in the healthy brain. also play role neurodegeneration causing dementia. However, it is not clear what brain morphometry most useful identifying critical to their involvement neurodegeneration. Method We examined network from four measures of cortical morphometry, derived using anatomical T1-weighe...

As a complex network of many interlinked brain regions, there are some central hub regions which play key roles in the structural human brain network based on T1 and diffusion tensor imaging (DTI) technology. Since most studies about hubs location method in the whole human brain network are mainly concerned with the local properties of each single node but not the global properties of all the d...

In the enterprise application software industry, dominant system vendors (hubs) have formed strategic partnerships with small software companies (spokes), resulting in the emergence of hub-and-spoke networks. Based upon the concept of software stacks, we argue that the governance mechanisms applied by hub and spokes depend on the complementarity between hub's and spoke's resources. Specifically...

We address the problem of message transfer in a communication network. The network consists of nodes and links, with the nodes lying on a two-dimensional lattice. Each node has connections with its nearest neighbors, whereas some special nodes, which are designated as hubs, have connections to all the sites within a certain area of influence. The degree distribution for this network is bimodal ...

Brain function operates through the coordinated activation of neuronal assemblies. Graph theory predicts that scale-free topologies, which include "hubs" (superconnected nodes), are an effective design to orchestrate synchronization. Whether hubs are present in neuronal assemblies and coordinate network activity remains unknown. Using network dynamics imaging, online reconstruction of functiona...

Hubs are highly connected proteins in a protein-protein interaction network. Previous work has implicated disordered domains and high surface charge as the properties significant in the ability of hubs to bind multiple proteins. While conformational flexibility of disordered domains plays an important role in the binding ability of large hubs, high surface charge is the dominant property in sma...

Hub facilities serve as switching and transshipment points in transportation and communication networks as well as in logistic systems. Hub networks have an influence on flows on the hub-to-hub links and ensure benefit from economies of scale in inter-hub transportation. The key factors for designing a successful hub-and-spoke network are to determine the optimal number of hubs, to properly loc...

Network biology and data mining processes are helpful enough to provide detailed information about the genes and their networks which paves the way for drug designing. Here, in this study the genes implicated in cancer such as Basal cell carcinoma (BCC), Squamous cell carcinoma (SCC), Throat cancer, Thyroid cancer and Oral cancer are retrieved and the network comprising co-expression, co-locali...

Many real-world networks contain highly connected nodes called hubs. Hubs are often crucial for network function and spreading dynamics. However, classical models of how hubs originate during network development unrealistically assume that new nodes attain information about the connectivity (for example the degree) of existing nodes. Here, we introduce hub formation through nonlinear growth whe...