We study a perishable inventory system that requires to maintain a minimum inventory volume at all times, where the minimum amount in the constraint is significant with respect to regular market demand and the traditional Economic Manufacturing Quantity (EMQ) models do not suffice. The problem is motivated by applications in homeland security, which are related to the management of pharmaceutic...

Supply chain management is concerned with the coordination of material and information flows in multi-stage production systems. Inventory management has long been treated as an isolated function solely focused on individual entities, taking into account concerned with single-vendor-single-buyer and single-vendormultiple-buyer-models. Concerning the supplier selection problem, quantitative model...

OBJECTIVE The most important cause of infant mortality during the first month of life is related to congenital abnormalities. Nevertheless, timely diagnosis of these diseases can reduce the severity of their effects. The present study aimed to investigate the cost-effectiveness of the neonatal screening program in Fars Province, Iran. METHODS In this study, costs of executing the screening pr...

This paper provides a simple model of platforms with direct network effects, in which users value not just the quantity (i.e. number) of other users who join, but also their average quality in some dimension. A monopoly platform is more likely to exclude low-quality users when users place more value on average quality and less value on total quantity. With competing platforms, the effect of use...

BACKGROUND Statins reduce the rates of heart attacks, strokes, and revascularization procedures (ie, major vascular events) in a wide range of circumstances. Randomized controlled trial data from 20,536 adults have been used to estimate the cost-effectiveness of prescribing statin therapy in the United States for people at different levels of vascular disease risk and to explore whether wider u...

Given a set of scenarios, we answer the question whether this set equals the set of all executions of a Petri net. Formally, scenarios are expressed by (isomorphism classes of) labelled partial orders (LPOs), also known as pomsets or partial words. An LPO is an execution of a Petri net if it is a sequentialization of an LPO generated by a process of the net. We propose a definition of regions f...

Abstract In a companion paper [Barb 90a,b], we proposed a Place/Transition-net (P/T-net) semantics for a subset of Lotos. This subset is such that Lotos .specifications can be translated into finite structure Petri nets. It is therefore possible to apply P/T-net verification techniques since they require finite structure. It this paper, we demonstrate that it is possible to apply P/T-net verifi...

OBJECTIVE To determine the net benefit and costs associated with gown use in preventing transmission of vancomycin-resistant Enterococcus (VRE). DESIGN A cost-benefit analysis measuring the net benefit of gowns was performed. Benefits, defined as averted costs from reduced VRE colonization and infection, were estimated using a matched cohort study. Data sources included a step-down cost alloc...

Raw material inventory is an important factor in supporting the company's production activities. purchase scheduling can increase productivity. When company faced with continuous demand, supplies control should be done optimally. This research aims to carry out of raw materials method Economic Order Quantity casing weaving Jenggolok hamlet, Gedangkulut Village Cerme-Gresik subdistrict. type qua...