The nuclear export of proteins is regulated largely through the exportin/CRM1 pathway, which involves the specific recognition of leucine-rich nuclear export signals (NESs) in the cargo proteins, and modulates nuclear-cytoplasmic protein shuttling by antagonizing the nuclear import activity mediated by importins and the nuclear import signal (NLS). Although the prediction of NESs can help to de...

LIM-kinase 1 (LIMK1) is a serine/threonine kinase that phosphorylates cofilin and regulates actin-filament dynamics. LIMK1, which contains two LIM domains and a single PDZ domain, localizes predominantly in the cytoplasm, but its mutant, deleted with the PDZ domain, localizes mainly in the nucleus, thereby indicating that the PDZ domain plays a role in the cytoplasmic localization of LIMK1. Her...

We propose a more realistic version of the recently introduced split-step model (SSM), which consists of periodically alternating dispersive and nonlinear segments, by adding uniformly distributed loss and lumped gain to it. In the case when the loss is exactly balanced by gain, a family of stable equilibrium solitons (ESs) is found. Unless the system’s period L is very small, saturation is obs...

s analysed scores for eight patients tested identically following amytal (30-40 mg) injected directly into a posterior cerebral artery (PCA), to the inactivate hippocampus without causing aphasia. Mean scores (maximum = 8) by dominance/pathology were: for ISA normal D = 6.4 ND = 4.2, pathological D = 35 ND = 21; for PCA, normal D = 7.5 ND = 7.7, pathological D = 5.0 ND = 2.0. On ISA normal D vs...

s analysed scores for eight patients tested identically following amytal (30-40 mg) injected directly into a posterior cerebral artery (PCA), to the inactivate hippocampus without causing aphasia. Mean scores (maximum = 8) by dominance/pathology were: for ISA normal D = 6.4 ND = 4.2, pathological D = 35 ND = 21; for PCA, normal D = 7.5 ND = 7.7, pathological D = 5.0 ND = 2.0. On ISA normal D vs...

In this minireview we will discuss recent progress in the analytical study of current-carrying nonequilibrium steady states (NESS) that can be constructed in terms of a matrix product ansatz. We will focus on one-dimensional exactly solvable strongly correlated cases, and will study both quantum models, and classical models which are deterministic in the bulk. The only source of classical stoch...

Department of Medicine B, Sheba Medical Center, Tel Hashomer, affiliated with Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel Division of Internal Medicine, Department of Medicine H, Soroka University Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel Department of Psychiatry, Ness Ziona Mental Health Center, Ness Ziona, Is...