Background Endometriosis is a common gynecological disease, can cause severe pelvic pain. Studies demonstrated the presence of sensory nerve fibers in endometrium of endometriosis patient. Nevertheless, no information is available on mechanisms of sensory nerve formation in eutopic or ectopic lesions. Since HOX genes have important roles in both reproductive tract and nerve growth, we decided t...

T HAS BEEN SHOWN that the myelin sheath and the surface membrane at the node of Ranvier of the myelinated nerve fiber behave, to a weak penetrating current, like a condenser with an ohmic resistance connected in parallel (1–5). The absolute values of these capacities and resistances have been estimated already with some accuracy. In order to analyze the process of action potential production at...

Purpose To devise a method to quantify nerve fibers over their arcuate courses over an extended peripapillary area using optical coherence tomography (OCT). Methods Participants were imaged with 8 × 8-mm volumetric OCT scans centered at the optic disc. A new quantity, nerve fiber flux (NFF), represents the cross-sectional area transected perpendicular to the nerve fibers. The peripapillary ar...

Imaging through the visual system in Alzheimer's disease, with the technology currently in widespread use for the diagnosis and management of eye disease such as glaucoma and macular degeneration, is proving to be promising. In vivo cross-section imaging during an annual comprehensive eye exam has been available for a decade for glaucoma and macular degeneration, and this same imaging, using Op...

BACKGROUND Skin biopsy is the most relevant tool to diagnose small-fiber neuropathy. A well-documented normal dataset for intraepidermal nerve fiber in the distal leg is required to improve its diagnostic value. METHODS Three hundred healthy subjects were enrolled in the study, after clinical and biological screening to exclude neurological and systemic pathologies. A distal leg biopsy was ta...

A new nerve fiber model has been developed, incorporating electrical characteristics of human myelinated sensory nerve fibers. It will be used to determine the response of myelinated somatosensory nerve fibers in the spinal cord to electrical stimulation with an epidurally placed electrode. Index terms Spinal cord stimulation, human sensory nerve fiber, simulated action potential, chronaxie dia...

Electron microscopic immunocytochemistry has been used to study the distribution and synaptic relationships of substance P (SP)-immunoreactive nerve fibers in ultrathin sections from whole-mount preparations of myenteric ganglia from guinea pig small intestine. At the light microscopic level, myenteric ganglia stained for ultrastructural study contained dense arrays of SP-immunoreactive nerve f...

In an initial report (Carbonetto, S. T., M. M. Gruver, and D. C. Turner (1982) Science 216: 897-899) we described the use of 2-hydroxyethylmethacrylate (HEMA) in preparing defined culture substrates for studying nerve fiber growth. In those studies fibronectin and collagen were conspicuous, among a variety of HEMA-embedded proteins, in supporting fiber growth of embryonic neurons from chick dor...