The treatment of systemic lupus erythematosus (SLE) nephritis, while effective, is associated with significant morbidity and mortality. These side effects could be mitigated if the onset, severity, and response of renal flare could be predicted, and therapy modified accordingly. In this review, an approach to derive prediction equations of SLE nephritis flare is discussed. Integral to generatin...

1. In experimental nephritis caused by cantharidin, arsenic, diphtheria toxin, and potassium chromate, in addition to the retention of the non-protein and urea nitrogen and of the chlorides in blood, an acidosis occurs. 2. Sodium bicarbonate given by the stomach has the power of diminishing the acidosis in these types of nephritis. 3. The degree of increase in the non-protein and urea nitrogen ...

Reference 1. Reddy PS, Legault HM, Sypek JP, Collins MJ, Goad E, Goldman SJ, Liu W, Murray S, Dorner AJ, O’Toole M: Mapping similarities in mTOR pathway perturbations in mouse lupus nephritis models and human lupus nephritis. Arthritis Res Ther 2008, 10:R127. Correction Correction: Mapping similarities in mTOR pathway perturbations in mouse lupus nephritis models and human lupus nephritis Padma...

Interstitial nephritis is a common cause of renal dysfunction. It is primarily caused by drugs, infections, or autoimmune disorders. Patients with human immunodeficiency virus (HIV) infection can develop interstitial nephritis, although it typically occurs because of the aforementioned etiologies and not as a direct consequence of HIV infection. Interstitial lesions may occur in patients with H...

Proliferative lupus nephritis is a strong predictor of morbidity and mortality in patients with systemic lupus erythematosus. Despite improvements in the management of lupus nephritis, a significant number of the patients do not respond to immunosuppressive therapy and progress to end-stage renal failure. In order to optimise the diagnostic strategy and treatment of patients with proliferative ...

Nephritis associated with a chronically infected ventriculoatrial shunt is known as shunt nephritis. A 6-year-old girl with prior history of a ventriculoatrial shunt presented complaining of fever and gross hematuria. Serum complement levels were decreased and a coagulase-negative S. epidermidis was cultured from her blood. The renal biopsy specimen showed features of membranoproliferative glom...

The immunization of experimental animals with heterologous or homologous renal antigens usually leads to the production of antikidney antibodies and, in some instances, to the development of glomerulonephritis. Early reports on the induction of glomerulonephritis by immunization of rats with renal antigens mixed with streptococcus (1) could not be confirmed (2, 3). However, in 1952, Steblay rep...

Acute nephritis of medium severity, affecting both glomeruli and tubules, was produced in rats by injections of anti-rat-kidney serum, given on 3 consecutive days. The course of the nephritis was markedly influenced by the type of diet which was fed. Rats tended to recover promptly from the induced nephritis when a low protein-high carbohydrate diet was given. On the other hand, in nephritic ra...

We report an unusual case of adenoviral nephritis in a 45-year-old woman who presented with fever, gross haematuria, acute kidney injury and obstructive uropathy 17 months following renal transplantation. Adenoviral nephritis was confirmed with immunohistochemistry. We identified 10 other published cases of adenoviral nephritis proven by immunohistochemistry. Obstructive uropathy has been repor...

Lupus nephritis leads to significant morbidity and mortality in patients with systemic lupus erythematous. Immunosuppressive agents are recommended in management of Class III, IV and V lupus nephritis. The goals of therapy are to control the disease and to prevent relapse while minimizing side-effects of therapy. Most of the evidences in managements of Class III and IV lupus nephritis comes fro...