The protein C pathway has an important function in regulating and modulating blood coagulation and ensuring patency of the microcirculation. Protein C deficiency leads to macro- and microvascular thrombosis. Congenital severe protein C deficiency is a life-threatening state with neonatal purpura fulminans and pronounced coagulopathy. Patients with heterozygous protein C deficiency have an incre...

Amalia Biron Research Institute of Thrombosis and Hemostasis, Chaim Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel; Pediatric Department, Laniado hospital, Netanya; Ruth and Bruce Rappoport Faculty of Medicine Technion, Haifa, Israel; Neonatology Unit Laniado hospital, Department of Pediatrics, Barzilai University Medical Center, Ashkel...

Umbilical artery catheters allow reliable blood sampling and blood pressure moniNon bacterial endocardial thrombosis in neonates Relationship to persistent fetal circulation J Pediatr 1982;100: 117-122. 2 Menahem S, Robbie MJ, Rajaduran VS Valvar vegetations in the neonate due to fetal endocarditis Int J Cardiology 1991; 32: 103-105. 3 Krous HF Neonatal nonbactenal thrombotic endocarditis Arch ...

A case of diffuse chorioangiomatosis leading to fetal hydrops, disseminated intravascular coagulopathy with massive umbilical vein thrombosis and fetal death is described. Although rare, this benign mesenchymatous malformation of the placenta should be kept in mind as a possible cause of neonatal morbidity. Prenatal diagnosis could prevent fetal death.

Neonatal purpura fulminans is a life threatening clinical entity characterized by extensive subcutaneous thrombosis and disseminated intravascular coagulation usually manifesting shortly after birth. We report an autosomal recessive form of the disease in a neonate who was diagnosed with compound heterozygosity for mutations in his protein C gene as the molecular basis of his disorder.

Neonatal purpura fulminans is a clinical entity characterised by echymotic skin lesions, consumptive coagulopathy and widespread micro and macro vascular thrombosis. This can be hereditary or secondary to acquired causes. Clinical presentation of hereditary Protein C deficiency can be solely limited to localised echymotic skin lesions in the early stage, with wide spread vascular thrombosis ens...