Objective: To find out prevalence, risk factors, severity and outcome of neonatal thrombocytopenia (TCP). Study Design: Prospective Observational study. Setting: Neonatal Intensive Care Unit (NICU) Children Hospital Complex Multan. Period: January 2020 to 2021. Material & Methods: A total 191 neonates admitted NICU during the study period were enrolled. special proforma was designed record ...

In this issue of Blood, Bakchoul et al explore a novel approach to the treatment of neonatal alloimmune thrombocytopenia (NAIT) in utero: shielding fetal platelets from maternal alloantibodies.

Thrombocytopenia is a common hematologic abnormality during pregnancy. It may be a diagnostic and management problem, and has many causes, some of them specific to pregnancy. We considered all singleton deliveries after 24 weeks of gestation between 2007 and 2012 in our third level centre. Women with a platelet count <100 × 109/L, but who did not suffer from the aforementioned diseases, were co...

Neonatal alloimmune thrombocytopenia (NAIT) is the most common cause of severe thrombocytopenia in an otherwise healthy newborn. The most serious complication is intracranial hemorrhage, which can occur either in the fetus or the newborn. Despite the known serious sequelae, both antenatal management and neonatal treatment modalities are plagued by the lack of gold standard evidence to appropria...

Introduction: Neonatal thrombocytopenia is defined as a platelet count &lt;150×10^9/L regardless of gestational-age. It results from hypo-proliferation in marrow or peripheral destruction platelets. Platelet can be rapidly measured using automated hematology analyzers, but smear remains best method. The causes neonatal are by time presentation into foetal (mainly TORCH infections), early (&lt; ...

Amalia Biron Research Institute of Thrombosis and Hemostasis, Chaim Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel; Pediatric Department, Laniado hospital, Netanya; Ruth and Bruce Rappoport Faculty of Medicine Technion, Haifa, Israel; Neonatology Unit Laniado hospital, Department of Pediatrics, Barzilai University Medical Center, Ashkel...

Fetal/neonatal alloimmune thrombocytopenia is the most common cause of severe thrombocytopenia in the fetus and in an otherwise healthy newborn. To counter the consequences of severe fetal thrombocytopenia, antenatal therapies have been implemented. Predictive parameters for fetal severe thrombocytopenia are important for the development of noninvasive strategy and tailored intervention. We rep...