the aim of the present study is to investigate the relationship between obsessive-compulsive symptoms (ocss) and negative and positive symptoms in schizophrenia.subjects of the study comprised of 31 schizophrenia with obsessive-compulsive symptoms (19 men and 12 women) selected by convenience sampling method from iran psychiatric hospital. the diagnoses were established on the basis of dsm-iv-t...

Negative symptoms are still a major obstacle in the recovery of schizophrenic patients. Many attempts to develop novel drugs affecting negative symptoms of schizophrenia have yielded insignificant results. This study evaluates the effects of bromocriptine, a dopamine agonist, on negative symptoms of schizophrenia utilizing a placebo-controlled crossover double-blind clinical trial. Methodology:...

Background: The negative symptoms of schizophrenia remain a major clinical challenge. Nortriptyline is a serotonin and noradrenalin reuptake inhibitor and belongs to secondary amine tricycles. The aim of this study is to evaluate the effect of nortriptyline on the negative symptoms of schizophrenia. Methods: This study is a six-week randomized placebo-control trial of nortriptyline or placebo a...

Background and Objective: Considering the hypothesis of the effects of the use of antioxidants such as ascorbic acid on the improvement of oxidative stress induced by schizophrenia, the present study was designed to investigate the effect of ascorbic acid as an adjunctive therapy with risperidone in controlling the symptoms of schizophrenia. Materials and Methods: This randomized clinical tria...

the wisconsin test card sorting test (wcst) is a neuropsychological test that has been suggested as a more specific test for frontal lobes dysfunctions. this study was designed to determine whether wcst is able to differentiate between iranian psychiatric patients with cognitive disorders and normal subjects, and whether wcst scores are related to severity of symptoms in depressive and schizoph...